Results 31 to 40 of about 6,534 (210)

Normalization of wall shear stress as a physiological mechanism for regulating maternal uterine artery expansive remodeling during pregnancy

FASEB BioAdvances, 2021
Outward remodeling of the maternal uterine circulation during pregnancy is essential for normal uteroplacental perfusion and pregnancy outcome. The physiological mechanism by which this process is regulated is unknown; we hypothesized that it involved ...
Eliyahu V. Khankin, Nga Ling Ko, Maurizio Mandalà, S. Ananth Karumanchi, George Osol   +4 more
doaj   +1 more source

Trophoblast plugs: impact on utero-placental haemodynamics and spiral artery remodelling [PDF]

Human Reproduction, 2018
How does trophoblast plugging impact utero-placental haemodynamics?Physiological trophoblast plug structures are dense enough to restrict flow of oxygenated blood to the intervillous space (IVS) in the first trimester, and result in a shear stress environment upstream of the plugs that promotes spiral artery remodelling.Trophoblast plugging of the ...
Joanna L James, Rojan Saghian, Rebecca Perwick, Alys R Clark   +3 more
openaire   +2 more sources

Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy [PDF]

Nature, 2012
In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear.
Cui, Yujie, Wang, Wei, Dong, Ningzheng, Lou, Jinglei, Srinivasan, Dinesh Kumar, Cheng, Weiwei, Huang, Xiaoyi, Liu, Meng, Fang, Chaodong, Peng, Jianhao, Chen, Shenghan, Wu, Shannon, Liu, Zhenzhen, Dong, Liang, Zhou, Yiqing, Wu, Qingyu   +15 more
openaire   +3 more sources

The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy

Frontiers in Cell and Developmental Biology, 2022
Chemerin is an adipokine that regulates metabolism in pregnancy. An elevation of serum chemerin level is associated with pregnancy complications. Consistently, we demonstrated that the chemerin expression was increased in placenta of preeclamptic ...
Qingqing Zhang, Qingqing Zhang, Zhonglin Xiao, Cheuk-Lun Lee, Cheuk-Lun Lee, Yong-Gang Duan, Xiujun Fan, William S. B. Yeung, William S. B. Yeung, Philip C. N. Chiu, Philip C. N. Chiu, Jian V. Zhang, Jian V. Zhang, Jian V. Zhang   +13 more
doaj   +1 more source

Trophoblast‐mediated spiral artery remodelling: a role for apoptosis

Journal of Anatomy, 2009
AbstractIn the first 20 weeks of pregnancy a number of important changes take place in the maternal uterine vasculature. Vascular endothelial and smooth muscle cells are lost from the spiral arteries and are replaced by fetal trophoblast cells. The resulting increase in blood flow to the intervillous space ensures that the fetus receives the nutrients ...
Guy St J, Whitley, Judith E, Cartwright
openaire   +3 more sources

Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling via Induction of G-CSF

Frontiers in Cell and Developmental Biology, 2020
Vitamin D deficiency is associated with complications of pregnancy such as pre-eclampsia, fetal growth restriction, and miscarriage, all of which are also associated with incomplete spiral artery (SpA) remodeling.
Joy Yue Zhang, Peihuang Wu, Danyang Chen, Fen Ning, Qinsheng Lu, Xiu Qiu, Martin Hewison, Jennifer A. Tamblyn, Mark D. Kilby, Mark D. Kilby, Gendie E. Lash   +10 more
doaj   +1 more source

Uterine Natural Killer Cells and Implantation

Fertility & Reproduction, 2021
Decidual leukocytes make up approximately 30% of all decidual stromal cells in early pregnancy, of which 70% are uterine natural killer (uNK) cells. uNK cells are phenotypically distinct from peripheral blood NK cells, being CD56brightCD16−.
Gendie E. Lash
doaj   +1 more source

Quantification of spiral artery remodelling using an Adobe Photoshop-based technique [PDF]

Reproduction, 2019
Abstract Uterine spiral arteries undergo remodelling in normal pregnancy, with replacement of the musculoelastic arterial media by fibrinoid containing extravillous trophoblast cells. Deficient spiral artery remodelling is associated with several adverse pregnancy outcomes.
Otun HA, Innes BA, Lash GE, Schiessl B, Ball E, Searle RF, Robson SC, Bulmer JN   +7 more
openaire   +3 more sources

Downregulation of Cullin 3 Ligase Signaling Pathways Contributes to Hypertension in Preeclampsia

Frontiers in Cardiovascular Medicine, 2021
Background: Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality; however, its etiology and pathophysiology remain obscure. PE is initiated by inadequate spiral artery remodeling and subsequent placental ischemia/hypoxia,
Ya Zhang, Gengru Jiang, Chong Zhang
doaj   +1 more source

Therapeutic benefit of mesenchymal stem cells in pregnant rats with angiotensin receptor agonistic autoantibody-induced hypertension: Implications for immunomodulation and cytoprotection

Hypertension in Pregnancy, 2017
Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus.
Dan Zhang, Lihua Fu, Leilei Wang, Lin Lin, Lihong Yu, Lijun Zhang, Tao Shang   +6 more
doaj   +1 more source