Results 41 to 50 of about 23,483 (241)

Dynamic modeling of uteroplacental blood flow in IUGR indicates vortices and elevated pressure in the intervillous space - a pilot study [PDF]

, 2017
Ischemic placental disease is a concept that links intrauterine growth retardation (IUGR) and preeclampsia (PE) back to insufficient remodeling of uterine spiral arteries. The rheological consequences of insufficient remodeling of uterine spiral arteries
Frank, Hans-Georg, Häussner, Eva, Koch, Franz V., Roth, Christian J., Rübelmann, Tanja, Schmitz, Christoph, Wall, Wolfgang A.   +6 more
core   +1 more source

Therapeutic benefit of mesenchymal stem cells in pregnant rats with angiotensin receptor agonistic autoantibody-induced hypertension: Implications for immunomodulation and cytoprotection

Hypertension in Pregnancy, 2017
Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus.
Dan Zhang, Lihua Fu, Leilei Wang, Lin Lin, Lihong Yu, Lijun Zhang, Tao Shang   +6 more
doaj   +1 more source

Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension [PDF]

, 2012
BACKGROUND: Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling.
Campbell, Kate, Chang, Chiwen, Colucci, Francesco, Exley, Andrew, Jones, Des, Long, Lu L., Machado, Rajiv, Morrell, Nicholas W., Ormiston, Mark L., Pepke-Zaba, Joanna, Riding, Alex, Soon, Elaine, Southwood, Mark, Toshner, Mark R., Treacy, Carmen, Trembath, Richard C., Trowsdale, John, Wills, Mark   +17 more
core   +1 more source

4307 Role of Pre-pregnancy Uterine Natural Killer Cells in Human Embryo Implantation

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Human placentation requires complex coordination between maternal and fetal cell types but remains incompletely understood. We hypothesize that uterine natural killer (uNK) cells, an immune cell type that increases in abundance during ...
Jessica Kanter, Sneha Mani, Scott Gordon, Monica Mainigi   +3 more
doaj   +1 more source

The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat [PDF]

, 2016
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse ...
Beattie, Elisabeth, Delles, Christian, Graham, Delyth, Guzik, Tomasz, Morgan, Hannah, Nosalski, Ryszard, Small, Heather Yvonne   +6 more
core   +1 more source

Mitochondrial ROS Accumulation Contributes to Maternal Hypertension and Impaired Remodeling of Spiral Artery but Not IUGR in a Rat PE Model Caused by Maternal Glucocorticoid Exposure

Antioxidants, 2023
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and ...
Jing Long, Yan Huang, Gang Wang, Zhengshan Tang, Yali Shan, Shiping Shen, Xin Ni   +6 more
doaj   +1 more source

Modeling superimposed preeclampsia using Ang II (Angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats [PDF]

, 2018
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and
Beattie, Elisabeth, Butler, Elaine, Dechend, Ralf, Graham, Delyth, Herse, Florian, McBride, Martin W., Morgan, Hannah L., Ritchie, Shona   +7 more
core   +2 more sources

Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]

, 2012
Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Burghard F. Klapp, Elke Winterhager, Gabriela Barrientos, Irene Tirado González, Nancy Freitag, Petra Moschansky, Petra von Kwiatkowski, Sandra M. Blois, Stefan Bauersachs, Teresa Otto, Victor L. J. L. Thijssen, Yan-Ling Wang   +11 more
core   +12 more sources

A Topological Data Analysis Study on Murine Pulmonary Arterial Trees with Pulmonary Hypertension [PDF]

arXiv, 2022
Pulmonary hypertension (PH), defined by a mean pulmonary arterial blood pressure above 20 mmHg, is a cardiovascular disease impacting the pulmonary vasculature. PH is accompanied by vascular remodeling, wherein vessels become stiffer, large vessels dilate, and smaller vessels constrict.
arxiv  

Insights into Early-Pregnancy Mechanisms: Mast Cells and Chymase CMA1 Shape the Phenotype and Modulate the Functionality of Human Trophoblast Cells, Vascular Smooth-Muscle Cells and Endothelial Cells

Cells, 2022
Spiral-artery (SA) remodeling is a fundamental process during pregnancy that involves the action of cells of the initial vessel, such as vascular smooth-muscle cells (VSMCs) and endothelial cells, but also maternal immune cells and fetal extravillous ...
Ningjuan Zhang, Anne Schumacher, Beate Fink, Mario Bauer, Ana Claudia Zenclussen, Nicole Meyer   +5 more
doaj   +1 more source