Results 41 to 50 of about 13,039 (280)

Hyperglycemia results in significant pathophysiological changes of placental spiral artery remodeling and angiogenesis, further contributing to congenital defects

Frontiers in Bioscience-Landmark, 2021
Introduction: Hyperglycemic conditions achieved during pregnancy have been shown to have detrimental effects to fetal development and increase the prevalence of childhood comorbidities.
Yushu Qin, Naomi McCauley, Zehuan Ding, Lauren Lawless, Zhimin Liu, Ke Zhang, Linglin Xie   +6 more
doaj   +1 more source

Maternal exposure to ambient PM2.5 causes fetal growth restriction via the inhibition of spiral artery remodeling in mice

Ecotoxicology and Environmental Safety, 2022
Background: Maternal exposure to ambient fine particulate matters (PM2.5) is associated with low birth weight (LBW) in offspring, but the underlying biological mechanisms are not yet fully understood.
Shimin Tao, Xuan Zhang, Fang Tian, Bin Pan, Renzhen Peng, Yuzhu Wang, Minjie Xia, Mingjun Yang, Jingying Hu, Haidong Kan, Yanyi Xu, Weihua Li   +11 more
doaj   +1 more source

Spiral artery blood flow during pregnancy: a systematic review and meta-analysis

BMC Pregnancy and Childbirth, 2020
Background Downstream remodeling of the spiral arteries (SpA) decreases utero-placental resistance drastically, allowing sustained and increased blood flow to the placenta under all circumstances.
Veronique Schiffer, Laura Evers, Sander de Haas, Chahinda Ghossein-Doha, Salwan Al-Nasiry, Marc Spaanderman   +5 more
doaj   +1 more source

Role of IDO1 in The Spiral Artery Remodeling During Pregnancy

During gestation, the trophoectoderm, the outer layer of the blastocyst, engages with the uterine wall to form the placenta, a temporary organ at the maternal-fetal vascular interface. To increase blood flow through the placenta, uterine spiral arteries transform into large, dilated, low-resistance vessels in which the endothelial layer has been ...
Dema Ghaban, Dema Ghaban, Alison Carey
openalex   +2 more sources

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD, Baker, PN, Cartwright, JE, Freeman, A, Harris, LK, Keogh, RJ, Whitley, GS   +6 more
core   +1 more source

Effect of hematopoietic stem cell on tumor necrosis factor- α expression, spiral artery remodeling and placental apoptosis in lead-exposed pregnant mice

Asian Pacific Journal of Reproduction, 2017
Objective: To evaluate the effectiveness of hematopoietic stem cell (HSC) on TNF-α expression, spiral artery remodeling, and placental apoptosis.Methods: The study used pregnant mice divided to five groups of treatment: Group 1, without treatment; Group ...
Widjiati, Suryo Kuncorojakti, Hendy Hendarto, Viski Fitri Hendrawan, Aulanni'am Aulanni'am   +4 more
doaj   +1 more source

A New Approach in Risk Stratification by Coronary CT Angiography. [PDF]

, 2014
For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks.
Budoff, Matthew J, Nakanishi, Rine
core   +3 more sources

Normalization of wall shear stress as a physiological mechanism for regulating maternal uterine artery expansive remodeling during pregnancy

FASEB BioAdvances, 2021
Outward remodeling of the maternal uterine circulation during pregnancy is essential for normal uteroplacental perfusion and pregnancy outcome. The physiological mechanism by which this process is regulated is unknown; we hypothesized that it involved ...
Eliyahu V. Khankin, Nga Ling Ko, Maurizio Mandalà, S. Ananth Karumanchi, George Osol   +4 more
doaj   +1 more source

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy. [PDF]

, 2010
The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Brosnihan, KB, Cartwright, JE, Dechend, R, Geusens, N, Hering, L, Herse, F, Huppertz, B, Luft, FC, Muller, DN, Pijnenborg, R, Staff, AC, Verlohren, S, Wenzel, K   +12 more
core   +1 more source

The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy

Frontiers in Cell and Developmental Biology, 2022
Chemerin is an adipokine that regulates metabolism in pregnancy. An elevation of serum chemerin level is associated with pregnancy complications. Consistently, we demonstrated that the chemerin expression was increased in placenta of preeclamptic ...
Qingqing Zhang, Qingqing Zhang, Zhonglin Xiao, Cheuk-Lun Lee, Cheuk-Lun Lee, Yong-Gang Duan, Xiujun Fan, William S. B. Yeung, William S. B. Yeung, Philip C. N. Chiu, Philip C. N. Chiu, Jian V. Zhang, Jian V. Zhang, Jian V. Zhang   +13 more
doaj   +1 more source