A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]
, 2012 Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank +4 more
core +2 more sources
Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function. [PDF]
, 2019 Maternal uterine artery blood flow is critical to maintaining the intrauterine environment, permitting normal placental function, and supporting fetal growth. It has long been believed that inadequate transformation of the maternal uterine vasculature is
Giorgione, V +3 more
core +1 more source
Uterine Natural Killer Cells and Implantation
Fertility & Reproduction, 2021 Decidual leukocytes make up approximately 30% of all decidual stromal cells in early pregnancy, of which 70% are uterine natural killer (uNK) cells. uNK cells are phenotypically distinct from peripheral blood NK cells, being CD56brightCD16−.
Gendie E. Lash
doaj +1 more source
Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]
, 2012 Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Burghard F. Klapp +11 more
core +7 more sources
Frontiers in Cell and Developmental Biology, 2020 Vitamin D deficiency is associated with complications of pregnancy such as pre-eclampsia, fetal growth restriction, and miscarriage, all of which are also associated with incomplete spiral artery (SpA) remodeling.
Joy Yue Zhang +10 more
doaj +1 more source
Downregulation of Cullin 3 Ligase Signaling Pathways Contributes to Hypertension in Preeclampsia
Frontiers in Cardiovascular Medicine, 2021 Background: Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality; however, its etiology and pathophysiology remain obscure. PE is initiated by inadequate spiral artery remodeling and subsequent placental ischemia/hypoxia,
Ya Zhang, Gengru Jiang, Chong Zhang
doaj +1 more source
Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction [PDF]
Hypertension, 2013 Failure to transform uteroplacental spiral arteries is thought to underpin disorders of pregnancy, including preeclampsia and fetal growth restriction (FGR). In this study, spiral artery remodeling and extravillous-cytotrophoblast were examined in placental bed biopsies from normal pregnancy (n=25), preeclampsia (n=22), and severe FGR (n ...
Fiona Lyall +2 more
openalex +4 more sources
Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy. [PDF]
Int J Dev Biol, 2014 Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth. Uterine spiral arteries form the nutrient supply line for the placenta and fetus. This vascular conduit undergoes gestation stage-specific remodeling
Soares MJ +4 more
europepmc +6 more sources
Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology? [PDF]
, 2017 The pathologies of the pregnancy complications pre-eclampsia (PE) and fetal growth restriction (FGR) are established in the first trimester of human pregnancy.
Cartwright, JE, Whitley, GS
core +1 more source
Hypertension in Pregnancy, 2017 Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus.
Dan Zhang +6 more
doaj +1 more source