Patient-specific predictions of aneurysm growth and remodeling in the ascending thoracic aorta using the homogenized constrained mixture model [PDF]
Biomechanics and Modeling in Mechanobiology, Springer Verlag,
2019, 18 (6), pp.1895-1913, 2019 In its permanent quest of mechanobiological homeostasis, our vascula-ture significantly adapts across multiple length and time scales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G\&R) has significantly improved our insights of the mechanobio-logical processes of diseases such as ...
arxiv +1 more source
A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]
, 2012 Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank +4 more
core +2 more sources
Manipulating CD4+ T Cell Pathways to Prevent Preeclampsia
Frontiers in Bioengineering and Biotechnology, 2022 Preeclampsia (PreE) is a placental disorder characterized by hypertension (HTN), proteinuria, and oxidative stress. Individuals with PreE and their children are at an increased risk of serious short- and long-term complications, such as cardiovascular ...
Eileen J. Murray +9 more
doaj +1 more source
Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta [PDF]
, 2017 BACKGROUND: Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. Spiral arteries with failure of physiologic
Bammerlin, Elaine +8 more
core +1 more source
Biomolecules, 2021 Preeclampsia (PE) is a serious disease that can be fatal for the mother and fetus. The two-stage theory has been proposed as its cause, with the first stage comprising poor placentation associated with the failure of fertilized egg implantation ...
Keiichi Matsubara +5 more
doaj +1 more source
Application and reduction of a nonlinear hyperelastic wall model capturing ex vivo relationships between fluid pressure, area and wall thickness in normal and hypertensive murine left pulmonary arteries [PDF]
arXiv, 2022 Pulmonary hypertension is a cardiovascular disorder manifested by elevated arterial blood pressure together with vessel wall stiffening and thickening due to alterations in collagen, elastin and smooth muscle cells. Hypoxia-induced (type 3) pulmonary hypertension can be studied in animals exposed to a low oxygen environment for prolonged time periods ...
arxiv
Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function. [PDF]
, 2019 Maternal uterine artery blood flow is critical to maintaining the intrauterine environment, permitting normal placental function, and supporting fetal growth. It has long been believed that inadequate transformation of the maternal uterine vasculature is
Giorgione, V +3 more
core +1 more source
Natural killer cell-mediated immunopathology in recurrent pregnancy losses
Exploration of Immunology, 2022 Natural killer (NK) cells have a dual role in human reproduction for maternal-fetal tolerance and protection from infection. During the ovarian cycle and pregnancy, peripheral NK (pNK) and uterine NK (uNK) cells dynamically change their proportions and ...
Thanh Luu +7 more
doaj +1 more source
Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology? [PDF]
, 2017 The pathologies of the pregnancy complications pre-eclampsia (PE) and fetal growth restriction (FGR) are established in the first trimester of human pregnancy.
Cartwright, JE, Whitley, GS
core +1 more source
Frontiers in Immunology, 2017 Uterine natural killer cells (uNKs) and mast cells (uMCs) are of crucial importance for spiral artery (SA) remodeling and placentation. Mice deficient for both NKs and MCs including uNKs and uMCs show markedly impaired SA remodeling and their fetuses are
Nicole Meyer +3 more
doaj +1 more source