Results 81 to 90 of about 23,483 (241)

A Multiscale Framework for Defining Homeostasis in Distal Vascular Trees: Applications to the Pulmonary Circulation [PDF]

arXiv, 2020
Coupling hemodynamics with vessel wall growth and remodeling (G&R) is crucial for understanding pathology at distal vasculature to study progression of incurable vascular diseases, such as pulmonary arterial hypertension. The present study is the first modeling attempt that focuses on defining homeostatic baseline values in distal pulmonary vascular ...
arxiv  

The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]

PLoS ONE 2013 May 22; 8(5): e63884, 2012
Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling.
arxiv   +1 more source

Materials Advances in Devices for Heart Disease Interventions

Advanced Materials, EarlyView.
This review examines the crucial role of materials in heart disease interventions, focusing on strategies for monitoring, managing, and repairing heart conditions. It discusses the material requirements for medical devices, highlighting recent innovations and their impact on cardiovascular health.
Gagan K. Jalandhra, Lauryn Srethbhakdi, James Davies, Chi Cong Nguyen, Phuoc Thien Phan, Zachary Och, Aditya Ashok, Khoon S. Lim, Hoang‐Phuong Phan, Thanh Nho Do, Nigel H. Lovell, Jelena Rnjak‐Kovacina   +11 more
wiley   +1 more source

Impaired trophoblast invasion and increased numbers of immune cells at day 18 of pregnancy in the mesometrial triangle of type 1 diabetic rats [PDF]

, 2015
IntroductionType 1 diabetes (T1D) is associated with adverse pregnancy outcome, usually attributed to hyperglycemia. Recently, we showed that pregnancy outcome in normoglycemic T1D rats was characterized by decreased fetal and placental weight ...
de Vos, P., Faas, M. M., Groen, B., Links, T. P., Uuldriks, G. A., Visser, J. T.   +5 more
core   +7 more sources

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

Frontiers in Immunology, 2021
Decidual natural killer (dNK) cells are the tissue-resident and major subpopulation of NK cells at the maternal-fetal interface. It has been demonstrated that dNK cells play pivotal roles in pregnancy, including keeping maternal-fetal immune tolerance ...
Yuefang Liu, Yuefang Liu, Yuefang Liu, Shujun Gao, Shujun Gao, Yangjing Zhao, Yangjing Zhao, Hui Wang, Hui Wang, Qiong Pan, Qixiang Shao, Qixiang Shao, Qixiang Shao   +12 more
doaj   +1 more source

The physical origin of aneurysm growth, dissection, and rupture [PDF]

arXiv, 2023
Rupture of aortic aneurysms is by far the most fatal heart disease, with a mortality rate exceeding 80%. There are no reliable clinical protocols to predict growth, dissection, and rupture because the fundamental physics driving aneurysm progression is unknown.
arxiv  

Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. [PDF]

, 2013
Transformation of the uterine spiral arteries (SAs) during pregnancy is critical to support the developing fetus, and is impaired in some pregnancy disorders, including preeclampsia.
Alison E. Wallace, Amanda J. Host, Ashton, Bilinski, Brosens, Bulmer, Cargnello, Cartwright, Cartwright, Dominguez, El Costa, Fraser, Grant, Guy S. Whitley, Hanna, Hannan, Harris, Hiby, Hiby, Hu, James, James, Jovanovic, Jovanovic, Judith E. Cartwright, Keogh, Knofler, Kofinas, LaMarca, Lash, Lash, Lash, Lash, Le Bouteiller, Martin, Melchiorre, Melchiorre, Naruse, Otun, Pijnenborg, Pijnenborg, Prefumo, Saito, Smith, Tabiasco, Trundley, Wallace, Wallace, Whitley   +48 more
core   +2 more sources

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

Finite element modelling of in-stent restenosis [PDF]

arXiv, 2020
From the perspective of coronary heart disease, the development of stents has come significantly far in reducing the associated mortality rate, drug-eluting stents being the epitome of innovative and effective solutions. Within this work, the intricate process of in-stent restenosis is modelled considering one of the significant growth factors and its ...
arxiv