Combating ageing beyond the cell: Emerging roles of extracellular proteostasis
The FEBS Journal, EarlyView.Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh +7 more
wiley +1 more source
B-Flow/Spatiotemporal Image Correlation M-Mode and Contrast-Enhanced/Microbubble Ultrasonography Quantification of Spiral Artery Distensibility and Placental Intervillous Perfusion in the First Trimester in a Primate Model of Impaired Spiral Artery Remodeling. [PDF]
Ultrasound Med Biol, 2023 Turan OM +5 more
europepmc +1 more source
Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su +6 more
wiley +1 more source
Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence
Journal of Periodontal Research, EarlyView.This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine +4 more
wiley +1 more source
Reuniting and Endolymphatic Duct Macrophages: Localization and Possible Roles
Audiology ResearchBackground: The inner ear hosts several macrophage populations. Endolymphatic sac macrophages can phagocytose otoconia, and spiral limbus macrophages express genes for fluid shear stress sensing and bone remodeling.
Elisa Vivado +2 more
doaj +1 more source
Medical SciencesPreeclampsia (PE) is not merely a pregnancy complication but a clinical manifestation of underlying vascular dysfunction with long-term health implications.
Kaltrina Kutllovci Hasani +2 more
doaj +1 more source
Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling. [PDF]
Placenta, 2021 Varberg KM, Soares MJ.
europepmc +1 more source
Surgical considerations based on oral and periodontal vascularization
Periodontology 2000, EarlyView.Abstract Objectives To synthesize current evidence on vascular and anastomotic patterns, emphasizing their operative implications for optimizing flap perfusion, neovascularization, and wound healing in periodontal and implant surgery, while accounting for anatomical variability and collateral circulation. Materials and Methods A comprehensive review of
Arvin Shahbazi +5 more
wiley +1 more source
Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight
Experimental Physiology, EarlyView.Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley +1 more source
Experimental Physiology, EarlyView.Abstract The clinical assessment of cardiovascular function during exercise using stress echocardiography is essential for accurate cardiac diagnosis. However, normal limitations of cardiac deformation responses to increasing physical exertion remain poorly understood.
Fabian Spahiu +4 more
wiley +1 more source