Results 121 to 130 of about 6,534 (210)

Gq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke

Glia, Volume 74, Issue 10, October 2026.
Chemogenetic activation of Gq signaling in microglia ahead of ischemic stroke reduces infarct size in mice. Seven days after stroke, Gq‐primed microglia in the penumbra show enhanced interferon responses, altered branching patterns, and reduced phagocytosis.
Lynn Bitar, Marie‐Luise Brehme, Charlotte Oldenburg, Sara Isla Cainzos, Michael G. Kaul, Tobias Mummert, Malte Borggrewe, Thomas G. Oertner, Tim Magnus   +8 more
wiley   +1 more source

Maternal blood endometase level as a predictive biomarker for hypertensive disorders during pregnancy: a prospective cohort study

Scientific Reports
Preeclampsia (PE) occurs due to inadequate spiral artery/trophoblast remodeling in early pregnancy. Endometases are involved in the remodeling of spiral arteries and placental trophoblasts.
Mustafa Can Sivas, Handan Turhan Karakus, Serkan Ozbey, Alper Gumus   +3 more
doaj   +1 more source

Ultrafast fMRI Detects Age‐Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1206-1218, September 2026.
ABSTRACT Purpose Aging impacts pulsatility of blood vessels in the brain, reflecting vascular health. Resolving characteristics of cardiac pulsatility requires faster acquisitions than traditional fMRI. An ultrafast fMRI method was developed and applied to sample several harmonics of cardiac pulsations at 7 T.
Charles Marchini, Dema Abdelkarim, Yuhui Chai, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton   +5 more
wiley   +1 more source

Prospective evaluation of the Simple Fetal Medicine Foundation's first‐trimester prediction model for preeclampsia in twin pregnancies

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1707-1716, September 2026.
The Simple Fetal Medicine Foundation model effectively predicts preeclampsia (PE) in twin pregnancies at 11 +0–13 + 6 weeks using only maternal risk factors and mean arterial pressure. It achieves a high detection rate for early onset PE (area under the receiver operating characteristic curve 0.911 for PE <30 weeks) and provides a simple, convenient ...
Cuilian Liu, Jiaxin Li, Yang Chen, Tianchen Wu, Qingnan Meng, Kuo Zhang, Yuan Wei   +6 more
wiley   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga, Silvia Frigo, Alessandro Cherubini, Eniada Rrapaj, Luca Valenti   +4 more
wiley   +1 more source

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi, Farzad Kamali, Bahareh Rabbani, Mehrdad Behmanesh, Nejat Mahdieh, Mehrdad Noruzinia   +5 more
wiley   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

The Immuno‐Cardiovascular Storm of Pre‐Eclampsia: Cytokine‐Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

IN VITRO MODEL FOR REMODELING OF THE SPIRAL ARTERY BY TROPHOBLASTIC CELLS

Juntendo Medical Journal, 2012
TARO KOSHIISHI, KEN-ICHI NAKAHAMA, XIANGLAN LI, SATORU TAKEDA, IKUO MORITA   +4 more
openaire   +2 more sources