Results 141 to 150 of about 6,534 (210)

SIRT Family: Biological Functions and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang   +9 more
wiley   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong   +8 more
wiley   +1 more source

Maternal Diet-Induced Excess Adiposity in Mice Disrupts Mid-Gestation Decidual Immune and Vascular Homeostasis Without Impairing Spiral Artery Remodeling. [PDF]

open access: yesActa Physiol (Oxf)
Bellissimo CJ   +11 more
europepmc   +1 more source

Lymphatic Endothelial Cells in Health and Disease

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang   +5 more
wiley   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

open access: yesMolecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia. [PDF]

open access: yesCell Mol Life Sci
Liu Y   +11 more
europepmc   +1 more source

Hyperpolarized MRI Detects Increased [1‐13C]Pyruvate Metabolism in Early Liver Regeneration

open access: yesNMR in Biomedicine, Volume 39, Issue 8, August 2026.
Hyperpolarized [1‐13C]pyruvate MRI detected increased pyruvate‐to‐lactate and pyruvate‐to‐alanine exchange during early liver regeneration following 70% partial hepatectomy in rats. These findings support the use of hyperpolarized MRI for noninvasive assessment of regenerative metabolism.
Uffe Kjærgaard   +8 more
wiley   +1 more source

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