Microbe Profile: Paracoccus denitrificans - a versatile model. [PDF]
Spiro S, Richardson DJ.
europepmc +1 more source
Toward Fully Biobased Polyesters With Spiroacetal Units: Synthesis and Enzymatic Depolymerization
A biobased spiroacetal‐containing dicarboxylate monomer derived from vanillin is developed as a sustainable alternative to dimethyl terephthalate. Copolyesters with tunable compositions are prepared, showing enhanced glass transition temperature, mechanical properties, and oxygen barrier performance.
Smita V. Mankar +9 more
wiley +1 more source
Fine-Tuning a Transformer Model for METTL3 Lead Optimization. [PDF]
Matter CM, Caflisch A.
europepmc +1 more source
ChemBang: Expanding the Chemical Space Around Small Molecules
Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales +3 more
wiley +1 more source
Promoted synthesis of spirooxindoles in the presence of chitosan containing an acidic ionic liquid bridge in aqueous medium. [PDF]
Amiri M, Seyedi N, Shirini F, Tajik H.
europepmc +1 more source
Dental composites: a comprehensive review on formulation, properties and recent developments
Dental composites are essential in modern restorative dentistry; this review covers their development, composition, key properties and recent advances, highlighting new technologies for optimizing materials and improving clinical outcomes. Abstract Dental composites have evolved considerably since their introduction, becoming the cornerstone of modern ...
Rayenne Latoui +2 more
wiley +1 more source
1,3-Dipolar Cycloaddition of Nitrile Imines and Nitrile Oxides to Exocyclic C=N Bonds-An Approach to <i>Spiro</i>-N-Heterocycles. [PDF]
Petrova JV +2 more
europepmc +1 more source
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami +9 more
wiley +1 more source
Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABA<sub>A</sub>Rs. [PDF]
Koinas DA, Zhou X, Bruzik KS, Miller KW.
europepmc +1 more source
ABSTRACT Aim To design and develop a novel co‐produced intervention tool aimed at facilitating discussions that lung cancer nurses have with lung cancer patients about clinical trial opportunities; and promote trial recruitment. Design A multi‐phase qualitative focus group (phase 1) and co‐production (phase 2) study.
Christopher Dodd +8 more
wiley +1 more source

