Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted [PDF]
Molecules, 2022 In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds.
Regina Westphal +11 more
doaj +2 more sources
Synthesis of Spiro Heterocyclic Compounds [PDF]
E-Journal of Chemistry, 2010 Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim +2 more
doaj +2 more sources
Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
doaj +2 more sources
Chemistry Teacher Trainees’ use of Molecular Models in Learning Spiro and Bicyclic Compounds
Science Education International, 2022 The study diagnosed chemistry teacher trainees’ difficulties in naming and writing structures of spiro and bicyclic compounds. The case study design was conducted in a constructivist environment to enhance chemistry teacher trainees’ ability to construct,
Claudia Quayson +3 more
doaj +1 more source
New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues
Molecules, 2021 Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling.
Alan X. Zhao +2 more
doaj +1 more source
Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity
Molecules, 2023 Based on the literature data from 1973 to 2022, this work summarizes reports on spiro-flavonoids with a spiro-carbon at the center of their structure and how this affects their isolation methods, stereochemistry, and biological activity.
Łukasz Pecio +3 more
doaj +1 more source
Scientific Reports, 2023 Spiro[benzo[h]quinoline-7,3′-indoline]diones and spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones were efficiently synthesized via one-pot multi-component reactions under ultrasound-promoted conditions.
Melek Gul +4 more
doaj +1 more source
An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones
Chemistry Proceedings, 2021 We have efficiently synthesized mono as well as bis and spiro cyclic products of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by refluxing a reaction mixture of the three components in deep eutectic solvent (DES) to generating “libraries from libraries ...
Nilesh S. Pawar +2 more
doaj +1 more source
Molecules, 2022 Spiro-fused polycyclic aromatic compounds (PACs) have received growing interest as rigid chiral scaffolds. However, furan-containing spiro-fused PACs have been quite limited.
Koji Nakano, Ko Takase, Keiichi Noguchi
doaj +1 more source
Synthesis and Characterization of a Three Rings Heterocyclic Spiro Furan and Evaluation of its Cytotoxicity Properties on G-292 Cell Lines [PDF]
شیمی کاربردی روز, 2021 Synthesis and study of the medicinal properties of new spiro compounds with various functional groups is of great interest to organic and pharmaceutical researchers because of their special structure and conformation. Multi-component reactions are one of
Mona Besharat +2 more
doaj +1 more source