Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted [PDF]
Molecules, 2022 In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds.
Regina Westphal +11 more
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Molecules, 2022 Spiro-fused polycyclic aromatic compounds (PACs) have received growing interest as rigid chiral scaffolds. However, furan-containing spiro-fused PACs have been quite limited.
Koji Nakano, Ko Takase, Keiichi Noguchi
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Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
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Synthesis of Spiro-Bridged 3,4-Dihydrocoumarins Through an Organocatalytic Cascade Sequence Diels–Alder/Nucleophilic Ring Closing [PDF]
Molecules3,4-dihydrocoumarins and spiro compounds constitute an important class of privileged frameworks present in a wide variety of natural and synthetic molecules with diverse applications.
Alberto Medina-Ortíz +4 more
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A deep eutectic solvent mediated synthesis of spiro[naphthalene-2,5′-pyrimidine]-4-carbonitriles and their in silico inhibitory potential against the SARS-CoV-2 main protease [PDF]
RSC AdvancesA green and efficient deep eutectic solvent (DES)-mediated multicomponent strategy has been developed for the synthesis of spiro[naphthalene-2,5′-pyrimidine]-4-carbonitriles.
Ankita Chaudhary +3 more
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Synthesis and Crystal Structures of Two Novel O, N-Containing Spiro Compounds
Crystals, 2016 Two novel O, N-containing spiro compounds, C16H16ClNO4 (1) and C16H16N2O6 (2), were prepared by reactions of monosubstituted benzenamine (substituent = –NO2, –Cl) and 1,5-dioxaspiro[5.5]undecane-2,4-dione in ethanol solution of trimethoxymethane.
Wulan Zeng, Jinhe Jiang
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Chemistry Teacher Trainees’ use of Molecular Models in Learning Spiro and Bicyclic Compounds
Science Education International, 2022 The study diagnosed chemistry teacher trainees’ difficulties in naming and writing structures of spiro and bicyclic compounds. The case study design was conducted in a constructivist environment to enhance chemistry teacher trainees’ ability to construct,
Claudia Quayson +3 more
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New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues
Molecules, 2021 Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling.
Alan X. Zhao +2 more
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Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity
Molecules, 2023 Based on the literature data from 1973 to 2022, this work summarizes reports on spiro-flavonoids with a spiro-carbon at the center of their structure and how this affects their isolation methods, stereochemistry, and biological activity.
Łukasz Pecio +3 more
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Scientific Reports, 2023 Spiro[benzo[h]quinoline-7,3′-indoline]diones and spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones were efficiently synthesized via one-pot multi-component reactions under ultrasound-promoted conditions.
Melek Gul +4 more
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