Results 11 to 20 of about 11,270 (260)

Synthesis and Characterization of New Spiroheterocyclic from Isatin and Evaluation of Some Their Antifungal and Antibacterial Activity [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Spiro compounds Spiro cycles are widely found in natural products, medicines, and functional materials[1] the spiro atom forces the planes of the two rings to almost face one another, spiro compounds are a desirable subclass of heterocyclic scaffolds. In
Zubaida Al-Heety, Ali Al-Nasseri
doaj   +1 more source

New 6′-Amino-5′-cyano-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-pyridine]-3′-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity

Molecules, 2023
The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds.
Victor V. Dotsenko, Nawras T. Jassim, Azamat Z. Temerdashev, Zainab R. Abdul-Hussein, Nicolai A. Aksenov, Inna V. Aksenova   +5 more
doaj   +1 more source

Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

Journal of Taibah University for Science, 2017
A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3 ...
M. Sapnakumari, B. Narayana, K.S. Shashidhara, B.K. Sarojini   +3 more
doaj   +1 more source

Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

Molecules, 2010
Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives.
Mohamed Mohamed Youssef, Mahmoud Ahmed Amin   +1 more
doaj   +1 more source

The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles

Molecules, 2005
The tert-amino reaction effect was examined. A new method to synthesize spiro heterocycles is presented. It was shown that the “tert-amino effect” could be applied to the formation of spiro-fused heterocycles.
Y. Morzherin, O. Eltsov, L. Dyudya, T. Glukhareva, E. D’yachenko   +4 more
doaj   +1 more source

Synthesis of Spiro Heterocyclic Compounds

E-Journal of Chemistry, 2010
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim, Mohamed F. El-Messmary, Mohamed G. A. Elarfi   +2 more
doaj   +1 more source

Novel Rearrangements in the Reactions Directed Toward Preparation of Spiro-N,N-ketals: Reactions of Naphthalene-1,8-diamine with Ninhydrin and Isatin

Molecules, 2012
Spiro-N,N-ketal 5, consisting of a phthaloperine heterocyclic ring and a naphtha[1,8-ef][1,4]diazepine ring, was obtained along with spiro-N,N-ketal 2 via 2,2-condensation in the reaction of ninhydrin with naphthalene-1,8-diamine.
Keiji Kobayashi, Junko Kimura, Reiko Aoyama, Hideyuki Seto, Motoko Akita   +4 more
doaj   +1 more source

Synthesis and evaluation of the antioxidant activity of new spiro-1,2,4-triazine derivatives applying Ag/Fe3O4/CdO@MWCNT MNCs as efficient organometallic nanocatalysts

Frontiers in Chemistry, 2022
We applied the Petasites hybridus rhizome water extract as green media so that Ag/Fe3O4/CdO@ multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe3O4/CdO@MWCNTs MNCs) could be prepared.
Elham Ezzatzadeh, Somayeh Soleimani-Amiri, Zinatossadat Hossaini, Khatereh Khandan Barani   +3 more
doaj   +1 more source

Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities

Acta Pharmaceutica, 2016
6ʹ-(4-Chlorophenyl)-spiro[cyclohexane-1,2ʹ-thieno[3,2-d][1,3] oxazin]-4ʹ(1ʹH)-one (1) was synthesized and used as a starting material for the synthesis of a novel series of spiro compounds having biologically active sulfonamide 2a-e and 3ʹ-(4 ...
Hafez Hend N., El-Gazzar Abdel-Rhman B. A., Zaki Magdi E. A.   +2 more
doaj   +1 more source

Desing, synthesis and anti-inflammatory activity of dirivatives 10-R-3-aryl-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones of spiro-fused cyclic frameworks

Acta Chimica Slovenica, 2017
Present work is devoted to the purposeful search of novel promising anti-inflammatory agents among the insufficiently known 3'-R-10'-R1-spiro[hetaryl-3(4),6'-[1,2,4]triazino[2,3-c]quinazolin]-2'(7'H)-ones.
Oleksandra Kolomoets, Oleksii Voskoboynik, Oleksii Antypenko, Galyna Berest, Inna Nosulenko, Vitaliy Palchikov, Olexandr Karpenko, Sergiy Kovalenko   +7 more
doaj   +1 more source