Results 191 to 200 of about 33,667 (245)

Mineralocorticoid Receptor Antagonists in Dialysis.

Am J Nephrol
Elenjickal EJ, Mavrakanas TA.
europepmc   +1 more source

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The spironolactone renaissance

Expert Opinion on Investigational Drugs, 2001
Until recently, spironolactone was considered only as an antagonist at the aldosterone receptors of the epithelial cells of the kidney and was used clinically in the treatment of hyperaldosteronism and, occasionally, as a K(+)-sparing diuretic. The spironolactone renaissance started with the experimental finding that spironolactone reversed aldosterone-
Lindsay Brown, S A Doggrell
exaly   +6 more sources

Spironolactone in dermatology

Dermatologic Therapy, 2022
Spironolactone is a drug, similar in structure to aldosterone and acts as an aldosterone receptor antagonist with an anti-androgenic effect. This drug has proven to be useful in several dermatological entities, however its use has not been well explored.
Diana Alejandra, Aguilar Medina, Jorge, Cazarín, Mario, Magaña   +2 more
openaire   +2 more sources

Beneficial impact of spironolactone in diabetic nephropathy [PDF]

Kidney International, 2005
Beneficial impact of spironolactone in diabetic nephropathy.BackgroundAldosterone has been suggested to play a role in the initiation and progression of diabetic nephropathy.
Peter Rossing, Kasper Rossing, Lise Tarnow   +2 more
exaly   +2 more sources

Novel spironolactone-analogs as impurities in spironolactone

Steroids, 2004
Six novel spironolactone-analogs steroids (3-8) were isolated from spironolactone by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. Two of the analogs (3 and 7) were confirmed by X-ray crystallography.
Hua, Chen, Xiao-Yi, Wang, Zhong-Duo, Yang, Yuan-Chao, Li   +3 more
openaire   +2 more sources

Readministration of Spironolactone in the Spironolactone-Intolerant Patient

Allergy and Asthma Proceedings, 1986
We report a successful practical protocol for readministration of spironolactone in a patient with cirrhosis and severe ascites whose initial exposure to spironolactone resulted in erythema multiforme. Because salt and water restriction and other diuretics were ineffective, readministration of spironolactone was considered appropriate.
P A, Greenberger, H P, Lazar
openaire   +2 more sources

Safety of low-dose spironolactone administration in chronic haemodialysis patients

Nephrology Dialysis Transplantation, 2003
BACKGROUND Prevention of cardiovascular diseases is essential in chronic haemodialysis patients. Recently, low-dose spironolactone has been shown to decrease cardiovascular mortality in patients with severe heart failure.
Pierre-Yves Martin, Patrick Saudan
exaly   +2 more sources

Spironolactone for hypertension

Cochrane Database of Systematic Reviews, 2010
Spironolactone is an aldosterone antagonist, considered fourth line therapy for hypertension in patients already treated with multiple medications.Primary: to determine the effect of spironolactone on patient mortality, morbidity, and to quantify the magnitude of blood pressure lowering effect of spironolactone monotherapy.Secondary: to determine the ...
Josh, Batterink, Sarah N, Stabler, Aaron M, Tejani, Curt T, Fowkes   +3 more
openaire   +2 more sources

Tolerance of spironolactone

British Journal of Dermatology, 1988
A survey of 54 patients taking spironolactone for hirsutes or acne showed that side-effects occurred in 91%; in 80% of patients, these were related to the anti-androgenic mechanism of the drug (menstrual disturbances, and breast enlargement and tenderness).
B R, Hughes, W J, Cunliffe
openaire   +2 more sources