Results 201 to 210 of about 34,497 (254)
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Dermatologic Therapy, 2022
Spironolactone is a drug, similar in structure to aldosterone and acts as an aldosterone receptor antagonist with an anti-androgenic effect. This drug has proven to be useful in several dermatological entities, however its use has not been well explored.
Diana Alejandra, Aguilar Medina +2 more
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Spironolactone is a drug, similar in structure to aldosterone and acts as an aldosterone receptor antagonist with an anti-androgenic effect. This drug has proven to be useful in several dermatological entities, however its use has not been well explored.
Diana Alejandra, Aguilar Medina +2 more
openaire +2 more sources
The spironolactone renaissance
Expert Opinion on Investigational Drugs, 2001Until recently, spironolactone was considered only as an antagonist at the aldosterone receptors of the epithelial cells of the kidney and was used clinically in the treatment of hyperaldosteronism and, occasionally, as a K(+)-sparing diuretic. The spironolactone renaissance started with the experimental finding that spironolactone reversed aldosterone-
Lindsay Brown, S A Doggrell
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Novel spironolactone-analogs as impurities in spironolactone
Steroids, 2004Six novel spironolactone-analogs steroids (3-8) were isolated from spironolactone by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. Two of the analogs (3 and 7) were confirmed by X-ray crystallography.
Hua, Chen +3 more
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Readministration of Spironolactone in the Spironolactone-Intolerant Patient
Allergy and Asthma Proceedings, 1986We report a successful practical protocol for readministration of spironolactone in a patient with cirrhosis and severe ascites whose initial exposure to spironolactone resulted in erythema multiforme. Because salt and water restriction and other diuretics were ineffective, readministration of spironolactone was considered appropriate.
P A, Greenberger, H P, Lazar
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Spironolactone for hypertension
Cochrane Database of Systematic Reviews, 2010Spironolactone is an aldosterone antagonist, considered fourth line therapy for hypertension in patients already treated with multiple medications.Primary: to determine the effect of spironolactone on patient mortality, morbidity, and to quantify the magnitude of blood pressure lowering effect of spironolactone monotherapy.Secondary: to determine the ...
Josh, Batterink +3 more
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Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone
Circulation Research, 2018 Rationale: Resistant hypertension is a major health concern with unknown cause. Spironolactone is an effective antihypertensive drug, especially for patients with resistant hypertension, and is ...
Norbert Leitinger +2 more
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British Journal of Dermatology, 1988
A survey of 54 patients taking spironolactone for hirsutes or acne showed that side-effects occurred in 91%; in 80% of patients, these were related to the anti-androgenic mechanism of the drug (menstrual disturbances, and breast enlargement and tenderness).
B R, Hughes, W J, Cunliffe
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A survey of 54 patients taking spironolactone for hirsutes or acne showed that side-effects occurred in 91%; in 80% of patients, these were related to the anti-androgenic mechanism of the drug (menstrual disturbances, and breast enlargement and tenderness).
B R, Hughes, W J, Cunliffe
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Polymorphism of Spironolactone
Journal of Pharmaceutical Sciences, 1991Single crystals of two polymorphic and four solvated crystalline forms of spironolactone (C24H32O4S) were obtained using different solvents. The morphology, symmetry, and crystallographic parameters were determined for all crystal forms except for the one obtained from methanol.
V, Agafonov +4 more
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Neonatal Network, 1999
DIURETICS ARE COMMONLY USED IN the neonatal intensive care unit (NICU) to remove excess extracellular fluid secondary to various diseases, such as chronic lung disease (CLD) and congestive heart failure (CHF). Diuretics are among the most used of all medications across age groups.
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DIURETICS ARE COMMONLY USED IN the neonatal intensive care unit (NICU) to remove excess extracellular fluid secondary to various diseases, such as chronic lung disease (CLD) and congestive heart failure (CHF). Diuretics are among the most used of all medications across age groups.
openaire +2 more sources