Results 51 to 60 of about 50,320 (220)

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Spironolactone may have prognostic benefit in selected patients with heart failure with preserved ejection fraction. This study assessed the myocardial tissue effects of spironolactone in heart failure with preserved ejection fraction. Methods
Adam K. McDiarmid, Peter P. Swoboda, Bara Erhayiem, Katrina A. Bounford, Petra Bijsterveld, Keith Tyndall, Graham J. Fent, Pankaj Garg, Laura E. Dobson, Tarique A. Musa, James R. J. Foley, Klaus K. Witte, Mark T. Kearney, John P. Greenwood, Sven Plein   +14 more
doaj   +1 more source

Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes.
Sudeep R. Aryal, Mohammed Siddiqui, Oleg F. Sharifov, Megan D. Coffin, Bin Zhang, Krishna K. Gaddam, Himanshu Gupta, Thomas S. Denney, Louis J. Dell'Italia, Suzanne Oparil, David A. Calhoun, Steven G. Lloyd   +11 more
doaj   +1 more source

Worsening renal function and outcome in heart failure patients with reduced and preserved ejection fraction and the impact of angiotensin receptor blocker treatment: data from the CHARM-study programme [PDF]

, 2016
Aims We investigated the association between worsening renal function (WRF) that occurs during renin–angiotensin–aldosterone system inhibition initation and outcome in heart failure (HF) patients with preserved ejection fraction (HFPEF) and compared ...
Brenner, Clark, Damman, Damman, Damman, Hillege, Lesogor, Lewis, Lindenfeld, Massie, McAlister, McMurray, National Institute for Health and Clinical Excellence, Pfeffer, Rossignol, Rossignol, Rusinaru, Swedberg, Testani, Vardeny, Yancy, Yusuf   +21 more
core   +1 more source

The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

Clinical, Cosmetic and Investigational Dermatology, 2023
Chaofan Wang, Yimei Du, Lingbo Bi, Xuewen Lin, Min Zhao, Weixin Fan Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Weixin Fan, Department of Dermatology, The ...
Wang C, Du Y, Bi L, Lin X, Zhao M, Fan W
doaj  

The prevalence of resistant arterial hypertension and secondary causes in a cohort of hypertensive patients: a single center experience [PDF]

, 2017
The prevalence of resistant hypertension (RHT) still remains unknown. Aim of the study was to investigate in a large cohort of hypertensive patients the prevalence of RHT, and to identify in these patients the secondary forms of arterial hypertension (SH)
Concistre, Antonio, Costi, Umberto, D'Ermo, Giuseppe, DE TOMA, Giorgio, DE VINCENTIS, Giuseppe, Iannucci, Gino, Letizia, Claudio, Lucia, Piernatale, Marinelli, Cristiano, Matteo, Galassi, Olmati, Federica, Pergolini, Mario Sergio, Petramala, Luigi, Tonnarini, Gian Franco   +13 more
core   +2 more sources

Comparative effectiveness and safety of eplerenone and spironolactone in patients with heart failure: a systematic review and meta-analysis

BMC Cardiovascular Disorders
Background Eplerenone and spironolactone, recognized as mineralocorticoid receptor antagonists (MRAs), have been reported to improve clinical prognosis among individuals diagnosed with heart failure (HF).
Ahmed Elshahat, Ahmed Mansour, Mohamed Ellabban, Ahmed Diaa, Atef Hassan, Ahmed Fawzy, Omar Abdulrahman Saad, Moaz Abouelmagd, Mahmoud Eid, Ahmed Elaraby, Mohamed Hamouda Elkasaby, Ahmed Abdelaziz   +11 more
doaj   +1 more source

Novel approach to adherence assessment based on parent drug and metabolite pharmacokinetics: pilot study with spironolactone

Biomedical Papers
Aim. The aim of this study was to evaluate adherence to spironolactone in a group of unselected patients with arterial hypertension by analysis of measured serum spironolactone and canrenone concentrations according to a proposed two-step decision scheme
Alena Pilkova, Martin Sima, Jan Miroslav Hartinger, Thi Minh Phuong Nikrynova Nguyen, Vera Maresova, Ivana Kurcova, Ondrej Slanar, Jiri Widimsky   +7 more
doaj   +1 more source

Association between dosing of spironolactone and outcomes in heart failure with preserved ejection fraction patients combined with chronic kidney disease------Balance of efficacy and risk

Frontiers in Pharmacology, 2023
Aims: Few studies have compared the association between dosing of spironolactone and outcomes in patients with heart failure with preserved ejection fraction (HFpEF), and whether spironolactone dose could significantly affect the prognosis of HFpEF ...
Jun-Feng Li, Xiang Qu, Zhan Gao, Chang-Xi Chen, Feng-Yu Zhang, Ling Cheng, Xi Zhou, Hao Zhou   +7 more
doaj   +1 more source

Addition of spironolactone in patients with resistant hypertension: A meta-analysis of randomized controlled trials

Clinical and Experimental Hypertension, 2017
This study was designed to assess the effect of additional spironolactone on blood pressure in patients with resistant hypertension. MEDLINE, EMBASE, and Cochrane Library were searched to identify randomized controlled trials (RCTs) that determined the ...
Liping Liu, Bing Xu, Yunfeng Ju
doaj   +1 more source

Spironolactone use is associated with improved outcomes in heart failure with mid‐range ejection fraction

ESC Heart Failure, 2020
Aims Spironolactone has been shown to improve outcomes in patients with heart failure (HF) with reduced ejection fraction (EF). We investigated whether the discharge use of spironolactone could be associated with better long‐term outcomes among patients ...
Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Taiki Higo, Miyuki Tsuchihashi‐Makaya, Hiroyuki Tsutsui   +6 more
doaj   +1 more source