Results 61 to 70 of about 50,320 (220)

Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs.

PLoS ONE
ObjectiveTo characterize the dose-exposure-response effect of spironolactone on biomarkers of the classical and alternative arms of the renin-angiotensin-aldosterone system (RAAS) in healthy dogs.AnimalsTen healthy purpose-bred Beagle dogs ...
Allison K Masters, Jessica L Ward, Emilie Guillot, Oliver Domenig, Lingnan Yuan, Jonathan P Mochel   +5 more
doaj   +1 more source

Adapting clinical guidelines to take account of multimorbidity [PDF]

, 2012
Most people with a chronic condition have multimorbidity, but clinical guidelines almost entirely focus on single conditions. It will never be possible to have good evidence for every possible combination of conditions, but guidelines could be made more ...
Alderson, P., Guthrie, B., McMurdo, M.E.T., Mercer, S.W., Payne, K.   +4 more
core   +1 more source

Spironolactone and colitis: Increased mortality in rodents and in humans [PDF]

, 2012
Background: Crohn's disease causes intestinal inflammation leading to intestinal fibrosis. Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality. We examined whether spironolactone is antifibrotic in the context
Akbar K. Waljee, Andres, Brenda W. Gillespie, Carter, Charlson, Chun, Deyo, Ersoy, Fan, Gullulu, Higgins, Huang, Ibrahim, Jarvis, Joel C. Joyce, Kamath, Kim, Kuehne, Kyne, Laura A. Johnson, Livak, Louis, Lyerly, Lyras, Mezzano, Nishimura, Ochs, Overdiek, Patel, Peter D.R. Higgins, Pitt, Powell, Rajagopalan, Sands, Semler, Shail M. Govani, Sungaila, Thannickal, Tian, Tox, Witteck   +40 more
core   +1 more source

Effect of spironolactone on pain responses in mice [PDF]

, 2010
The effects of spironolactone, a non-selective aldosterone antagonist, were examined on thermally-induced pain using the hot-plate and tail-flick tests, on hemogenic pain induced by intraplantar capsaicin, on electrically-induced pain, on visceral ...
Abdel-Salam, Omar M.E., Baiuomy, Ayman R., Nada, Somaia A.   +2 more
core  

Safety of low-dose spironolactone administration in chronic haemodialysis patients [PDF]

, 2017
Background. Prevention of cardiovascular diseases is essential in chronic haemodialysis patients. Recently, low-dose spironolactone has been shown to decrease cardiovascular mortality in patients with severe heart failure.
Fumeaux, Zina, Mach, Francois, Martin, Pierre-Yves, Perneger, Thomas, Rossier, Michel, Saudan, Patrick, Schnetzler, Bruno, Stoermann, Catherine   +7 more
core  

Urinary peptide-based classifier CKD273: towards clinical application in chronic kidney disease [PDF]

, 2017
Capillary electrophoresis coupled with mass spectrometry (CE-MS) has been used as a platform for discovery and validation of urinary peptides associated with chronic kidney disease (CKD).
Mischak, Harald, Pontillo, Claudia
core   +1 more source

Disease characteristics and outcomes in patients with chronic kidney disease and type 2 diabetes: a matched cohort study of spironolactone users and non-users

BMC Nephrology, 2020
Background Limited evidence has indicated that addition of a steroidal mineralocorticoid receptor antagonist (MRA) to the standard of care reduces proteinuria in patients with diabetic kidney disease (DKD); however, there are limited data regarding real ...
Michael Blankenburg, Csaba P. Kovesdy, Anne-Kathrin Fett, Raymond G. Griner, Alain Gay   +4 more
doaj   +1 more source

Anti-Fibrosis Effect of Relaxin and Spironolactone Combined on Isoprenaline-Induced Myocardial Fibrosis in Rats via Inhibition of Endothelial–Mesenchymal Transition

Cellular Physiology and Biochemistry, 2017
Background: The effect of relaxin and spironolactone combined on myocardial fibrosis has not been reported. Thus, we investigated the effect of the combined therapy on isoprenaline-induced myocardial fibrosis and the mechanism.
Jiejie Cai, Xiao Chen, Xingxing Chen, Lingzhi Chen, Gaoshu Zheng, Hao Zhou, Xi Zhou   +6 more
doaj   +1 more source

National survey of the prevalence, incidence, primary care burden, and treatment of heart failure in Scotland [PDF]

, 2004
Objective: To examine the epidemiology, primary care burden, and treatment of heart failure in Scotland, UK. Design: Cross sectional data from primary care practices participating in the Scottish continuous morbidity recording scheme between 1 April ...
Capewell, S., Chalmers, J., Kirkpatrick, M., MacIntyre, K., McAlister, F.A., McMurray, J., Murphy, N.F., Redpath, A., Simpson, C.R., Stewart, S.   +9 more
core   +2 more sources

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

Cellular Physiology and Biochemistry, 2015
Background: Fibrosis results in excessive buildup of extracellular matrix proteins along with abnormalities in structure and is partly derived by a process involving transforming growth factor β (TGF-β) called endothelial-to-mesenchymal transition (EndMT)
Xiao Chen, Jiejie Cai, Xi Zhou, Lingzhi Chen, Yongsheng Gong, Zhan Gao, Huaiqin Zhang, Weijian Huang, Hao Zhou   +8 more
doaj   +1 more source