Results 161 to 170 of about 808,301 (296)

Successful Management of Septic Splenitis in an Abyssinian Cat. [PDF]

Vet Med Sci
Sancho MV, Henry P, Taylor M, Davidson C, Muñoz ML, Llewellyn E, Vilfan M, Cazzini P, Morrison L, Blacklock K, Gunn-Moore D.   +10 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity. [PDF]

Sci Adv
Shein SA, Korchagina AA, Wang LJ, Lai Z, Chen Y, Fisher JS, Ludewig B, Lancaster JN, Fu YX, Koroleva E, Tumanov AV.   +10 more
europepmc   +1 more source

Cell mediated cytotoxicity against Sendai virus infected cells [PDF]

, 1976
Bevan, Bhatnagar, Brunner, Gardner, Gardner, Gordon, Julius, Kedar, Kieling, Koszinowski, Koszinowski, Koszinowski, Lagrange, Lesley, Mcfarland, Pfizenmaier, Rehn, Reif, Schmitt-Verhulst, Shearer, Wagner, Zinkernagel   +21 more
core   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Correction: Anti-lipid IgG antibodies are produced via germinal centers in a murine model resembling human lupus. [PDF]

Front Immunol
Wong-Baeza C, Reséndiz-Mora A, Donis-Maturano L, Wong-Baeza I, Zárate-Neira L, Yam-Puc JC, Calderón-Amador J, Medina Y, Wong C, Baeza I, Flores-Romo L.   +10 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Splenic pathologies: A pictorial review of common, wandering, twisting and rare presentations. [PDF]

SA J Radiol
Rumhumha AR, Mphephu PE, Gabuza LM.
europepmc   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Single-cell spatiotemporal mapping reveals a spleen-to-lung neutrophil axis in antiviral defense. [PDF]

Immun Inflamm
Yang Z, Cong B, Wang B, Liu S, Liu Y, Ren X, Cao X.   +6 more
europepmc   +1 more source