Results 61 to 70 of about 429,662 (223)

Spleen stiffness measurements using point shear wave elastography detects noncirrhotic portal hypertension in human immunodeficiency virus [PDF]

, 2019
Objectives:To assess the utility of spleen stiffness as a diagnostic tool inindividuals withHIV andnon-cirrhotic portal hypertension(NCPH).Design:The Philips EPIQ7TM, a newpoint shearwave elastography (pSWE) technique, was used to assess liver and spleen
Ahmad, Ayesha, Graham S. Cooke, Garvey, Lucy, Lucy Garvey, Taylor-Robinson, Simon, Ayesha K. Ahmad, Maurice, James, Sebastiana Atzori, Atzori, Sebastiana, Cooke, Graham, James B. Maurice, Simon D. Taylor-Robinson   +11 more
core   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
Aim of investigation. To estimate diagnostic value of liver and spleen elastography in patients with extrahepatic portal vein obstruction - non-cirrhotic portal vein thrombosis (PVT). Material and methods.
M. Yu. Nadinskaya, Ye. O. Liusina, Ch. S. Pavlov   +2 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Assessing the Role of Longitudinal Variability of Vertical Track Stiffness in the Long-Term Deterioration [PDF]

, 2016
The performance of the railway system in terms of dynamic loading is depending mainly on the track support conditions. Usually, the track stiffness is used as the main parameter to describe the support conditions and is defined as the ratio of the load ...
Ramos Andrade, Antonio, Grossoni, Ilaria, Bezin, Yann   +2 more
core   +3 more sources

Comparison of sound touch elastography and liver fibrosis scores in assessing high-risk esophageal varices in patients with liver cirrhosis

Xin yixue
PurposeTo evaluate and compare the diagnostic efficiency of sound touch elastography (STE) and liver fibrosis scores (APRI, FIB-4) for high-risk esophageal varices (HREV) in patients with liver cirrhosis, providing evidence for clinical application of ...
Xiaohong KUANG, Manli WU
doaj   +1 more source

Screening for esophageal varices in cirrhotic patients – Non-invasive methods

Annals of Hepatology, 2019
Variceal bleeding is a dramatic complication of cirrhosis. Primary prophylaxis against variceal bleeding is indicated for patients with high-risk varices.
Ângelo Z. Mattos, Fernando C. Schacher, Guilherme John Neto, Angelo A. Mattos   +3 more
doaj   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source