Results 81 to 90 of about 429,662 (223)

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

The Role of Lipopolysaccharide-Binding Protein in Hepatitis B-Related Cirrhosis: Is There a Link to Portal Hypertension?

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Background: Bacterial translocation plays a critical role in the pathogenesis of systemic inflammation in cirrhosis, particularly in cases related to chronic Hepatitis B infection.
Ety Febrianti, Suyata -, Legiran -, Imam Suprianto, Vidi Orba Busro, Muhamad Ayus Astoni, Anjab Akmal Sya'roni   +6 more
doaj   +1 more source

Approaches to the Diagnosis of Portal Hypertension: Non-Invasive or Invasive Tests?

Hepatic Medicine: Evidence and Research, 2021
Elton Dajti,1,2 Luigina Vanessa Alemanni,1,2 Giovanni Marasco,1,2 Marco Montagnani,1,2 Francesco Azzaroli1,2 1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences (DIMEC), University of Bologna,
Dajti E, Alemanni LV, Marasco G, Montagnani M, Azzaroli F   +4 more
doaj  

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Validation of Spleen Stiffness Measurement for Screening of High-risk Esophageal Varices Among Cirrhotic Patients in Indonesia: A Single-Center Cross-sectional Study

Acta Medica Indonesiana
Background: Spleen stiffness measurement (SSM) is a recently developed non-invasive method for predicting clinically significant portal hypertension and esophageal varices in compensated advanced liver disease or cirrhosis.
Saut Horas Hatoguan Nababan, Gita Aprilicia, Pitt Akbar, Kemal Fariz Kalista, Chyntia Olivia Maurine Jasirwan, Juferdy Kurniawan, Cosmas Rinaldi A. Lesmana, Andri Sanityoso Sulaiman, Irsan Hasan, Rino Alvani Gani   +9 more
doaj   +2 more sources

Association of arterial stiffness with single nucleotide polymorphism rs1333049 and metabolic risk factors [PDF]

, 2013
The electronic version of this article is the complete one and can be found online at: http://www.cardiab.com/content/12/1/93. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.
Veerapol Kukongviriyapan, Vichai Senthong, Suphawadee Phababpha, Upa Kukongviriyapan, Chatri Settasatian, Pyatat Tatsanavivat, Senggunprai, L, Nantarat Komanasin, Poungrat Pakdeechote, Pakdeechote, P, Komanasin, N, Tatsanavivat, P, Nongnuch Settasatian, Senthong, V, Phongsak Intharaphet, Stephen E Greenwald, Settasatian, C, Intharaphet, P, Kukongviriyapan, V, Kukongviriyapan, U, Phababpha, S, Greenwald, SE, Laddawan Senggunprai, Settasatian, N   +23 more
core   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Nonlinear vibration isolators with asymmetric stiffness

, 2012
A vibration source is commonly coupled to a receiving structure by a vibration isolator. A key trade-off in the choice of vibration isolator is the requirement for a wide frequency range of isolation without excessive static deflection.
Abolfathi, A.
core   +1 more source