Results 51 to 60 of about 9,543,267 (326)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The spleen in liver cirrhosis: revisiting an old enemy with novel targets
Journal of Translational Medicine, 2017 The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension.
Liang Li +6 more
doaj +1 more source
The influence of season, photoperiod, and pineal melatonin on immune function. [PDF]
, 1995 In addition to the well-documented seasonal cycles of mating and birth, there are also significant seasonal cycles of illness and death among many animal populations.
Demas, G +3 more
core +1 more source
Glycans from Fasciola hepatica modulate the host immune response and TLR-Induced maturation of dendritic cells [PDF]
, 2015 Helminths express various carbohydrate-containing glycoconjugates on their surface, and they release glycan-rich excretion/secretion products that can be very important in their life cycles, infection and pathology. Recent evidence suggests that parasite
Brossard, Natalie +8 more
core +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Comparison of Generic and Proprietary Sodium Stibogluconate for the Treatment of Visceral Leishmaniasis in Kenya. [PDF]
, 2001 OBJECTIVE: To compare the use of generic and proprietary sodium stibogluconate for the treatment of visceral leishmaniasis (kala-azar). METHODS: A total of 102 patients with confirmed kala-azar were treated in a mission hospital in West Pokot region ...
Davidson, R N +6 more
core +1 more source
Use of Rituximab in autoimmune hemolytic anemia associated with non-hodgkin lymphomas [PDF]
, 2011 The association between non-Hodgkin lymphomas and autoimmune disorders is a well-known event. Also autoimmune hemolytic anemia (AHA), although much more frequent in patients with chronic lymphocytic leukemia (CLL), has been described in this group of ...
Fozza, Claudio +1 more
core +4 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Abscess of the Spleen during Pregnancy: Case Report
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018 Background and Objectives: Abscess of the spleen is a rare disease, which its selective treatment is splenectomy. In this disease, medical treatment alone is not enough.
Mojdeh Bahadorzadeh +3 more
doaj
, 2012 It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Blount, Daniel G +10 more
core +1 more source