Results 91 to 100 of about 20,678 (288)
Advanced ScienceLiver metastasis is the main cause of cancer‐related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation.
Xurui Zhang +19 more
doaj +1 more source
, 2013 The presented data was derived from at least 5 independent experiments. (A) As previously observed for other cytokines in different cell preparations [2,3], native mitochondrial protein (5 µg/ml) induced significant TNFα release from cultured mouse Flt3L-
Elliott D. Crouser (219388) +4 more
core +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
In vitro splenocyte proliferation.
, 2015 In vitro proliferation response was investigated in Ifit2tm1.1Ebsb and Prdm11tm1.1ahl splenocyte cultures. (A) For B-cell activation, Ifit2tm1.1Ebsb splenocytes were cultured with 1 μg/ml anti-CD40 and 1 ng/ml IL-4 or 5 μg/ml anti-CD40 and 10 ng/ml IL-4 (
Klaus T. Jensen (476411) +16 more
core +1 more source
The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]
, 2009 Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Loehe, Florian +17 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang +13 more
wiley +1 more source
Splenocyte Plaque Assay for the Detection of Murine Leukemia Virus
Experimental Biology and Medicine, 1975 A modified XC assay for murine leukemia virus (MuLV) employing splenocytes taken directly from the animal is described. This modification can be more than 1000 times more sensitive than XC plaque assays employing tissue extracts. This technique should lend itself readily to the quantitation of infectious MuLV in defined populations of lymphoid cells.
Melief, C J +5 more
openaire +2 more sources
Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage
, 1998 Studies indicate that, whereas immune functions in males are depressed, they are enhanced in females after trauma hemorrhage. Moreover, castration of male mice (i.e., androgen depletion) before trauma hemorrhage prevented the depression of cell-mediated
Martin K. Angele +4 more
core +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
Immunomodulatory Effects of Tigecycline in Balb/C Mice
Acta Pharmaceutica, 2018 Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for
Elhayek Shada Y. +4 more
doaj +1 more source