Results 71 to 80 of about 20,678 (288)

Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein. [PDF]

PLoS ONE, 2016
Chemokine C-X-C motif receptor 3 (CXCR3) is a chemokine receptor that is mainly expressed by activated T lymphocytes. T cells play important roles in allergic pulmonary inflammation, which is a hallmark of asthma and elicits the localized accumulation of
Zhongjuan Liu, Huaxia Chen, Xiaolan Chen, Jinming Gao, Zijian Guo   +4 more
doaj   +1 more source

Glycyrrhetinic Acid Induced Apoptosis in Murine Splenocytes.

Biological and Pharmaceutical Bulletin, 2001
Glycyrrhetinic acid (GA) is known to inhibit glucocorticoid metabolism inhibiting 11beta-hydroxysteroid dehydrogenase (11beta-HSD). Moreover, GA administration to mice has been shown to affect the lymphoid organs through elevation of endogenous corticosterone concentration.
HORIGOME, Hiroshi, HOMMA, Masato, HIRANO, Toshihiko, OKA, Kitaro   +3 more
openaire   +3 more sources

Splenocyte transfer followed by inhaled LPS leads to pGVHD pathology.

, 2014
Rag1−/− mice received allogeneic (Allo) or syngeneic (Syn) splenocytes or no splenocyte transfer (Rag1−/−NT). Additional wild-type C57BL/6 (B6) mice without splenocyte transfer (B6NT) were used as controls.
Stavros Garantziotis (225990), Margaret E. Nelson (566393), Jesse Sun (566391), Tereza Martinu (566389), Scott M. Palmer (293318), Christine V. Kinnier (566390), Francine L. Kelly (566392), W. Michael Foster (306647)   +7 more
core   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist

, 2001
In addition to marked seasonal changes in reproductive, metabolic, and other physiological functions, many vertebrate species undergo seasonal changes in immune function.
Staci D. Bilbo, Randy J. Nelson, Deborah L. Drazen, Donna Bilu   +3 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Daily and seasonal rhythms in immune responses of splenocytes in the freshwater snake, Natrix piscator.

PLoS ONE, 2015
Present study was designed to examine daily and seasonal variability in the innate immune responses of splenocytes in the fresh water snake, Natrix piscator.
Manish Kumar Tripathi, Ramesh Singh, Atanu Kumar Pati   +2 more
doaj   +1 more source

1,2,3,4,6-Penta-O-galloyl-.BETA.-D-glucose Protects Splenocytes against Radiation-Induced Apoptosis in Murine Splenocytes

Biological and Pharmaceutical Bulletin, 2010
Antioxidant property and hematopoietic repair capacity are important characteristics of radioprotective agents. Some studies have demonstrated that 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a molecule isolated from the waterlily, has antioxidant, hematopoietic repair, and anti-inflammatory activities.
Bing, So Jin, Kim, Min Ju, Park, Eunjin, Ahn, Ginnae, Kim, Dae Seung, Ko, Ryeo Kyeong, Lee, Nam Ho, Shin, Taekyun, Park, Jae Woo, Jee, Youngheun   +9 more
openaire   +3 more sources

l-Arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow

, 1999
Several studies indicate that immune responses are markedly depressed early after onset of hemorrhage. Decreased organ blood flow has been implicated in the pathophysiology of altered immune responses after trauma-hemorrhage.
Martin K. Angele, Alfred Ayala, Nadia Smail, Irshad H. Chaudry, William G. Cioffi, Markus W. Knöferl   +5 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source