Results 61 to 70 of about 17,686 (257)

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

The Effects of Ayurved Siriraj Wattana Recipe on Splenocytes in Wistar Rat

Siriraj Medical Journal, 2017
Wattana Ayurved Siriraj herbal formulary® has been used for decades and is quoted to carry anti-ageing action. Here, we have investigated the immunological efficacy and the safety for the consumption of Ayurved Siriraj Watana Recipe in Wistar rats.
Sunisa Duangsa-ard, Adisak Wongkajornsilp, Pravit Akarasereenont, Sukit Huabprasert, Tanta Chongputtharaksa, Tawee Laohapand   +5 more
doaj  

Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice

Molecules, 2011
8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice.
Wenhui Qian, Guoren Huang, Xuming Deng, Guanghong Xie, Xue Shen, Shuang Guan, Jing Lu   +6 more
doaj   +1 more source

1,2,3,4,6-Penta-O-galloyl-.BETA.-D-glucose Protects Splenocytes against Radiation-Induced Apoptosis in Murine Splenocytes

Biological and Pharmaceutical Bulletin, 2010
Antioxidant property and hematopoietic repair capacity are important characteristics of radioprotective agents. Some studies have demonstrated that 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a molecule isolated from the waterlily, has antioxidant, hematopoietic repair, and anti-inflammatory activities.
Bing, So Jin, Kim, Min Ju, Park, Eunjin, Ahn, Ginnae, Kim, Dae Seung, Ko, Ryeo Kyeong, Lee, Nam Ho, Shin, Taekyun, Park, Jae Woo, Jee, Youngheun   +9 more
openaire   +3 more sources

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Characterization and bioactivities of a novel polysaccharide obtained from Gracilariopsis lemaneiformis

Anais da Academia Brasileira de Ciências
Gracilariopsis lemaneiformis is a type of red alga that contains seaweed polysaccharide agar. In this study, a novel non-agar seaweed polysaccharide fraction named GCP (short of crude polysaccharide obtained from Gracilariopsis lemaneiformis) was ...
CHEN-SHAN SHI, YA-XIN SANG, GUI-QING SUN, TIAN-YE LI, ZHENG-SI GONG, XIANG-HONG WANG   +5 more
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Mechanical Force‐Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

Advanced Science
Liver metastasis is the main cause of cancer‐related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation.
Xurui Zhang, Na Huang, Yanhua Mu, Haiyan Chen, Mengchen Zhu, Shaoying Zhang, Pengfei Liu, Hailong Zhang, Huan Deng, Keping Feng, Qi Shang, Xi Liu, Chen Zhang, Mengjiao Shi, Lan Yang, Jin Sun, Guangyao Kong, Jing Geng, Shemin Lu, Zongfang Li   +19 more
doaj   +1 more source

Splenocyte Plaque Assay for the Detection of Murine Leukemia Virus

Experimental Biology and Medicine, 1975
A modified XC assay for murine leukemia virus (MuLV) employing splenocytes taken directly from the animal is described. This modification can be more than 1000 times more sensitive than XC plaque assays employing tissue extracts. This technique should lend itself readily to the quantitation of infectious MuLV in defined populations of lymphoid cells.
Melief, C J, Datta, S K, Louie, S, Johnson, S, Melief, M, Schwartz, R S   +5 more
openaire   +2 more sources