Results 91 to 100 of about 69,111 (289)
Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Prenatal Diagnosis, EarlyView.ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell +6 more
wiley +1 more source
Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia
Journal of Medical Imaging and Radiation Oncology, EarlyView.ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes +2 more
wiley +1 more source
Bleeding Disorders in Children With Genetic Diseases: A Narrative Review
Acta Paediatrica, EarlyView.ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol +6 more
wiley +1 more source
Barriers to Medical Care Are Frequently Reported by Patients With Cirrhosis
Alimentary Pharmacology &Therapeutics, EarlyView.In a telephone‐based survey study among > 1000 patients with cirrhosis, the most frequent barriers to care included time to travel to clinic, long wait times for appointments, and difficulty scheduling visits. Several barriers to care significantly differed by study site but were generally consistent across racial and ethnic subgroups.
William Chai +14 more
wiley +1 more source
Clinical Case ReportsKey Clinical Message When a person has both HS and beta‐thalassemia, their clinical symptoms tend to be less severe. This is because these two conditions have contrasting features.
Sana Habibzadeh +4 more
doaj +1 more source
Myelofibrosis and allogeneic transplantation: critical points and challenges
Frontiers in OncologyNew available drugs allow better control of systemic symptoms associated with myelofibrosis (MF) and splenomegaly but they do not modify the natural history of progressive and poor prognosis disease.
Paola Ranalli +8 more
doaj +1 more source
When, which and how to switch: Navigating JAK inhibitors in myelofibrosis
British Journal of Haematology, EarlyView.Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan +2 more
wiley +1 more source
Iron overload in hereditary spherocytosis: Are genetic factors the cause?
British Journal of Haematology, EarlyView.Summary Non‐transfusional iron overload (IOL) in hereditary spherocytosis (HS) is poorly documented compared with other red blood cell disorders. We studied 13 HS adults with confirmed IOL to identify potential genetic factors. Using a next‐generation sequencing panel of 46 genes related to HS, anaemia and iron metabolism, we found no association ...
Lucie Donaty +6 more
wiley +1 more source