Results 81 to 90 of about 132,601 (358)

B-cell Prolymphocytic Leukemia in a Young Male [PDF]

, 2011
B-cell prolymphocytic leukemia [B-PLL] is a neoplasm of B prolymphocytes affecting the peripheral blood, bone marrow and spleen. The principal disease characteristics are massive splenomegaly with absent or minimal peripheral lymphadenopathy and a ...
Fernandes, H, Jayaprakash, C, Pailoor, K, Swethadri, GK   +3 more
core  

Spatial Effects of the Social Marketing of Insecticide-Treated Nets on Malaria Morbidity. [PDF]

, 2005
Randomized controlled trials have shown that insecticide-treated nets (ITNs) have an impact on both malaria morbidity and mortality. Uniformly high coverage of ITNs characterized these trials and this resulted in some protection of nearby non-users of ...
Anonymous, Binka FN, Charlwood JD, Fraser-Hurt N, Hightower AW, Lengeler C, Lines JD, Lines JD, Nevill CG, Wolfinger R   +9 more
core   +1 more source

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Advanced Science, EarlyView.
In ovarian tumors with high CMTM4 expression, exosomes transfer CMTM4 to macrophages, upregulating ICAM1 and promoting M2 polarization via p65 nuclear translocation. This suppresses immunity by increasing PD‐1 and Tregs while reducing CD8+ T cells.
Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han   +12 more
wiley   +1 more source

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji   +9 more
wiley   +1 more source

Preoperatively diagnosed isolated hydatid cyst of pancreatic head with triad of obstructive jaundice, left-sided portal hypertension and chronic pancreatitis

MAMC Journal of Medical Sciences, 2015
We report a rare case of young female with isolated pancreatic head hydatid cyst causing obstructive jaundice, left-sided portal hypertension, and chronic pancreatitis.
Pradeep Choudhary, Harsh Vardhan Khokhar, Yashant Aswani, Sangeeta Saxena   +3 more
doaj   +1 more source

A case report of a pregnant woman with compensated liver cirrhosis and pancytopenia

Clinical Case Reports, 2023
Key Clinical Message Liver cirrhosis may worsen during pregnancy resulting in adverse maternal and fetal outcomes. Proper antenatal evaluation, staging, and variceal screening will facilitate the management.
Sreenisha S. S, Abdulmalik Bako, Salwa Abo Yaqoub, Feazlin Mohd Din   +3 more
doaj   +1 more source

FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly

PLoS Neglected Tropical Diseases, 2016
Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) and splenomegaly (SplM). FOXP3+ Tregs could regulate inflammation, but it is unclear where these cells are produced and what roles they play in
A. Romano, X. Hou, M. Sertorio, H. Dessein, Sandrine Cabantous, P. Oliveira, Jun Li, Sandrine Oyegue, Violaine Arnaud, Xinsong Luo, Martine Chavanieu, O. Mariani, X. Sastre, A. Dombey, Hongbin He, Yuesheng Li, A. Dessein   +16 more
semanticscholar   +1 more source

Case report of an enigmatic childhood hematomalignancy

Journal of Pediatric Critical Care, 2019
Juvenile Myelomonocytic Leukemia (JMML) is a rare leukemia of children we are still in the process of unraveling presenting a frustrating and dismal picture.
M Geetha, B Kiran, Madhusmitha Jena, V Rangaiah, Nikhila R Reddy, T Himabindu   +5 more
doaj   +1 more source

Splenomegaly, hypersplenism, and hereditary disorders with splenomegaly

Open Journal of Genetics, 2013
Splenomegaly, sometimes of massive extent, occurs in a large number of hereditary diseases, some relatively prevalent and others, rare to ultra-rare. Because physicians are often unfamiliar with the less common disorders, patients may suffer because of diagnostic delay or diagnostic error and may undergo invasive, non-innocuous procedures such as ...
Neal J. Weinreb, Barry E. Rosenbloom
openaire   +3 more sources

Systemic Mastocytosis in 910 Patients: Prognostic Contribution of the International Consensus Classification in the Context of the Mayo Alliance Prognostic System

American Journal of Hematology, EarlyView.
Overall survival data among 910 Mayo Clinic patients with systemic mastocytosis stratified by the International Consensus Classification (ICC) and the Mayo Alliance Prognostic Scoring System (MAPS). ABSTRACT The current study includes 910 patients with systemic mastocytosis (SM) seen at the Mayo Clinic from 1968 to 2024.
Fnu Aperna, Maymona G. Abdelmagid, Mahesh Kumar, Joseph H. Butterfield, Thanai Pongdee, Cecilia Y. Arana Yi, Mrinal S. Patnaik, Daniel A. Arber, Attilio Orazi, Dong Chen, Kaaren K. Reichard, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi   +13 more
wiley   +1 more source