Results 1 to 10 of about 395,684 (337)

SpliceFinder: ab initio prediction of splice sites using convolutional neural network

BMC Bioinformatics, 2019
Background Identifying splice sites is a necessary step to analyze the location and structure of genes. Two dinucleotides, GT and AG, are highly frequent on splice sites, and many other patterns are also on splice sites with important biological ...
Ruohan Wang, Zishuai Wang, Jianping Wang, Shuaicheng Li   +3 more
doaj   +2 more sources

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3’ splice sites [PDF]

RNA Biology
SF3B1 is a core component of the spliceosome involved in branch point recognition and 3’ splice site selection. The SF3B1 K700E mutation (lysine to glutamic acid) is common in myelodysplastic syndrome and other blood disorders.
Austin Herbert, Abigail Hatfield, Alexandra Randazza, Valeria Miyamoto, Katie Palmer, Lela Lackey   +5 more
doaj   +2 more sources

Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells [PDF]

Viruses
Human T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis.
Shuanglong Wei, Bohan Zhang, Jingwan Han, Hanping Li, Yongjian Liu, Lei Jia, Jingyun Li, Xiaotian Huang, Lin Li   +8 more
doaj   +2 more sources

Prediction and Quantification of Splice Events from RNA-Seq Data.

PLoS ONE, 2016
Analysis of splice variants from short read RNA-seq data remains a challenging problem. Here we present a novel method for the genome-guided prediction and quantification of splice events from RNA-seq data, which enables the analysis of unannotated and ...
Leonard D Goldstein, Yi Cao, Gregoire Pau, Michael Lawrence, Thomas D Wu, Somasekar Seshagiri, Robert Gentleman   +6 more
doaj   +2 more sources

A basic framework to explain splice-site choice in eukaryotes [PDF]

Nature Communications
Changes in splicing can mediate phenotypic variation, ranging from flowering time differences in plants to genetic diseases in humans. Splicing changes occur due to differences in splice-site strength, often influenced by genetic variation and the ...
Craig I. Dent, Stefan Prodic, Aiswarya Balakrishnan, Aaryan Chhabra, James D. G. Georges, Sourav Mukherjee, Jordyn Coutts, Michael Gitonobel, Rucha D. Sarwade, Joseph Rosenbluh, Mauro D’Amato, Partha P. Das, Ya-Long Guo, Alexandre Fournier-Level, Richard Burke, Sridevi Sureshkumar, David Powell, Sureshkumar Balasubramanian   +17 more
doaj   +2 more sources

Widespread use of non-productive alternative splice sites in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
Saccharomyces cerevisiae has been used as a model system to investigate the mechanisms of pre-mRNA splicing but only a few examples of alternative splice site usage have been described in this organism.
Tadashi Kawashima, Stephen Douglass, Jason Gabunilas, Matteo Pellegrini, Guillaume F Chanfreau   +4 more
doaj   +2 more sources

Investigation of Tensile Strength of Welded Splices of Steel Bars [PDF]

Journal of Structural and Construction Engineering, 2021
Due to the increasing need to use rebar in construction, many efforts have been made to optimize its use. One way to reduce rebar usage is to use welded splice instead of overlap splice. However, the Iranian Concrete Code only refers to the welded splice
Pouyan Ashrafpour, Mohsen Adabi, Ehsan Darvishan, Siyavash Moeini   +3 more
doaj   +1 more source

The Effect of Welded Splice with Predetermined Gap of Concrete Spun Pile on The Response of Low Strain Integrity Test

Civil Engineering Dimension, 2022
This paper presents the velocity wave of concrete spun piles with welded splice. The stress wave velocity was recorded using Pile Integrity Test. Two specimens were prepared in the experiment.
Gogot Setyo Budi, Levin S. Tanaya
doaj   +1 more source

CADD-Splice—improving genome-wide variant effect prediction using deep learning-derived splice scores

Genome Medicine, 2021
Splicing of genomic exons into mRNAs is a critical prerequisite for the accurate synthesis of human proteins. Genetic variants impacting splicing underlie a substantial proportion of genetic disease, but are challenging to identify beyond those occurring
Philipp Rentzsch, M. Schubach, J. Shendure, Martin Kircher   +3 more
semanticscholar   +1 more source

Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies

Science, 2023
Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Michael W. Baughn, Ze’ev Melamed, Jone López-Erauskin, Melinda S. Beccari, K. Ling, A. Zuberi, Maximilliano Presa, E. Gonzalo-Gil, R. Maimon, Sonia Vazquez-Sanchez, Som Chaturvedi, M. Bravo-Hernández, V. Taupin, Stephen Moore, Jonathan W. Artates, Eitan S. Acks, I. S. Ndayambaje, A. R. Agra de Almeida Quadros, Paayman Jafar-nejad, F. Rigo, C. Bennett, C. Lutz, C. Lagier-Tourenne, D. Cleveland   +23 more
semanticscholar   +1 more source