Results 151 to 160 of about 395,684 (337)
Advanced Optical Materials, EarlyView.Incorporating lanthanide‐based fluorophores into commercial resists for femtosecond direct laser writing enables a novel platform for multiplexed sensing. Porous, periodic, and solid luminescent microstructures fabricated directly on optical fiber tips are presented.
Valese Aslani +8 more
wiley +1 more source
DeepSplice: a deep learning approach for accurate prediction of alternative splicing events in the human genome [PDF]
Mohammad Abrar +8 more
openalex +1 more source
Advanced Science, EarlyView.Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian +26 more
wiley +1 more source
The evolution of splicing: transcriptome complexity and transcript distances implemented in TranD [PDF]
, 2021 Adalena V. Nanni +7 more
openalex +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein [PDF]
, 1988 James P. Trempe, B J Carter
openalex +1 more source
Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS
Advanced Science, EarlyView.This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu +14 more
wiley +1 more source
A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake [PDF]
, 1998 Peter J. Gough +2 more
openalex +1 more source