Results 161 to 170 of about 395,684 (337)

Archaic hominin traits through the splicing lens [PDF]

, 2023
Maxime Rotival
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Functional studies on the ATM intronic splicing processing element

, 2005
Marzena Anna Lewandowska
openalex   +1 more source

Isolation and characterization of post-splicing lariat–intron complexes [PDF]

, 2008
Rei Yoshimoto, Naoyuki Kataoka, Katsuya Okawa, Mutsuhito Ohno   +3 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Negative Regulation of Virus-triggered IFN-β Signaling Pathway by Alternative Splicing of TBK1 [PDF]

, 2008
Weiwen Deng, Mude Shi, Meifang Han, Jin Zhong, Zhenhu Li, Weina Li, Yu Hu, Lingchen Yan, Jie Wang, Ying He, Hong Tang, Vincent Deubel, Xiaoping Luo, Qin Ning, Bing Sun   +14 more
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Decoding the interconnected splicing patterns of hepatitis B virus and host using large language and deep learning models. [PDF]

Microb Genom
Lim CS, Brown CM.
europepmc   +1 more source

Characterization of subcellular localization and stability of a splice variant of G alphai2

, 2002
Philip Wedegaertner
openalex   +1 more source

Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources [PDF]

, 2018
Dinanath Sulakhe, Mark D’Souza, Sheng Wang, Sandhya Balasubramanian, Prashanth Athri, Bingqing Xie, Stefan Canzar, Gady Agam, T. Conrad Gilliam, Natalia Maltsev   +9 more
openalex   +1 more source