Results 281 to 290 of about 394,248 (332)

Profiling of RBM20-Regulated CaMKIIδ Splice Variants Across the Heart, Skeletal Muscle, and Olfactory Bulbs. [PDF]

Genes Cells
Maeda Y, Yamasu Y, Kuroyanagi H.
europepmc   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Cracking rare disorders: a new minimally invasive RNA-seq protocol. [PDF]

NPJ Genom Med
De Cock L, D'haenens E, Vantomme L, Backers L, Beyens A, Claes KB, De Clercq G, de Putter R, Kumps C, Schuermans N, Sourbron J, Syryn H, Tavernier S, Vanbelleghem E, Vanakker O, Vandekerckhove B, Van Damme T, Callewaert B, Dheedene A, Vergult S, Menten B.   +20 more
europepmc   +1 more source

Dual‐Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures

Advanced Science, EarlyView.
A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng, Hufei Wang, Ming Li, Jianpeng Gao, Xiao Liu, Chuyue Zhang, Pengfei Chi, Bo Li, Yuan Xve, Daoyang Fan, Zheng Wang, Jianheng Liu, Xing Wang, Licheng Zhang   +13 more
wiley   +1 more source

The evolutionary path of the epithelial sodium channel δ-subunit in Cetartiodactyla points to a role in sodium sensing. [PDF]

Commun Biol
Zahnow F, Jäger C, Mohamed Y, Vogelhuber G, May F, Ciocan AM, Manieri A, Maxeiner S, Krasteva-Christ G, Schnappauf O, Cobain MRD, Podsiadlowski L, Crespo-Picazo JL, García-Párraga D, Althaus M.   +14 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Contribution of neuroligin and neurexin alternative splicing to the establishment of enteric neuronal synaptic specificity. [PDF]

Am J Physiol Gastrointest Liver Physiol
D'Autréaux F, Chalazonitis A, Arumugam D, Gershon T, Gershon MD.   +4 more
europepmc   +1 more source

A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans.

, 1989
Xuming Huang, David Hirsh
openalex   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

New genetic diagnoses for inherited retinal dystrophies by integrating splicing tools into NGS pipelines. [PDF]

NPJ Genom Med
Fernández-Suárez E, González-Del Pozo M, Méndez-Vidal C, Martín-Sánchez M, Mena M, García-Nuñez A, Bravo-Gil N, Morillo-Sánchez MJ, Rodríguez-de la Rúa E, Borrego S, Antiñolo G.   +10 more
europepmc   +1 more source