Results 21 to 30 of about 395,684 (337)
Molecular Cell, 2007 A novel study in a recent issue of Molecular Cell (Shi and Manley, 2007) provides insight into a complex signaling pathway that controls the phosphorylation status of an SR-related protein that functions as a splicing repressor following heat shock-dependent dephosphorylation.
Guil, Sonia, Cáceres, Javier F.
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Dysregulation and Therapeutic Targeting of RNA Splicing Variants in Cancer [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعيةmRNA splicing constitutes a crucial biological phenomenon characterized by the excision of introns from pre-mRNA, followed by the synthesis of mature mRNA through the concatenation of the remaining exons.
Doaa Rabaya, Ghaleb Adwan
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Benchmarking deep learning splice prediction tools using functional splice assays
Human Mutation, 2020 Hereditary disorders are frequently caused by genetic variants that affect pre‐messenger RNA splicing. Though genetic variants in the canonical splice motifs are almost always disrupting splicing, the pathogenicity of variants in the noncanonical splice ...
Tabea V. Riepe +4 more
semanticscholar +1 more source
Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites
Cells, 2020 Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence ...
Katharina Frey, Boas Pucker
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Molecular cloning, expression, and functional features of IGF1 splice variants in sheep
Endocrine Connections, 2021 Insulin-like growth factor 1 (IGF1), also known as somatomedin C, is essential for the regulation of animal growth and development. In many species, the IGF1 gene can be alternatively spliced into multiple transcripts, encoding different pre-pro-IGF1 ...
Xu-Ting Song +10 more
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Genome-wide analyses supported by RNA-Seq reveal non-canonical splice sites in plant genomes
BMC Genomics, 2018 Background Most eukaryotic genes comprise exons and introns thus requiring the precise removal of introns from pre-mRNAs to enable protein biosynthesis. U2 and U12 spliceosomes catalyze this step by recognizing motifs on the transcript in order to remove
Boas Pucker, Samuel F. Brockington
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GC content around splice sites affects splicing through pre-mRNA secondary structures
BMC Genomics, 2011 Background Alternative splicing increases protein diversity by generating multiple transcript isoforms from a single gene through different combinations of exons or through different selections of splice sites.
Chen Liang, Kuo CC Jay, Zhang Jing
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Human Mutation, 2016 The purpose of the dbNSFP is to provide a one‐stop resource for functional predictions and annotations for human nonsynonymous single‐nucleotide variants (nsSNVs) and splice‐site variants (ssSNVs), and to facilitate the steps of filtering and ...
Xiaoming Liu +3 more
semanticscholar +1 more source
Spliced leader RNA trans-splicing in dinoflagellates [PDF]
Proceedings of the National Academy of Sciences, 2007 Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Huan, Zhang +6 more
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TopHat: discovering splice junctions with RNA-Seq
Bioinform., 2009 Motivation: A new protocol for sequencing the messenger RNA in a cell, known as RNA-Seq, generates millions of short sequence fragments in a single run.
Cole Trapnell +2 more
semanticscholar +1 more source