Results 31 to 40 of about 395,684 (337)
Spliced-Leader trans-Splicing in Freshwater Planarians [PDF]
Molecular Biology and Evolution, 2005 trans-Splicing, in which a spliced-leader (SL) RNA is appended to the most 5' exon of independently transcribed pre-mRNAs, has been described in a wide range of eukaryotes, from protozoans to chordates. Here we describe trans-splicing in the freshwater planarian Schmidtea mediterranea, a free-living member of the phylum Platyhelminthes.
Ricardo M, Zayas +2 more
openaire +2 more sources
iMapSplice: Alleviating reference bias through personalized RNA-seq alignment. [PDF]
PLoS ONE, 2018 Genomic variants in both coding and non-coding sequences can have functionally important and sometimes deleterious effects on exon splicing of gene transcripts.
Xinan Liu, James N MacLeod, Jinze Liu
doaj +1 more source
CD44 splice isoform switching determines breast cancer stem cell state
Genes & Development, 2019 Zhang et al. show that manipulating the splicing regulator ESRP1 to shift alternative splicing from splice isoform CD44v to CD44s leads to an induction of cancer stem cell properties.
Honghong Zhang +13 more
semanticscholar +1 more source
Genome Biology, 2023 Predicting the impact of coding and noncoding variants on splicing is challenging, particularly in non-canonical splice sites, leading to missed diagnoses in patients.
Patricia J. Sullivan +17 more
doaj +1 more source
Genetics in Medicine, 2019 Using exome sequencing, the underlying variants in many persons with autosomal recessive diseases remain undetected. We explored autosomal recessive Stargardt disease (STGD1) as a model to identify the missing heritability.
Riccardo Sangermano +29 more
semanticscholar +1 more source
Flexural performance of reinforced HS-HVFA-SCC beam with spliced plain bar
SN Applied Sciences, 2022 This research presents the use of flexural performance criteria for determining the required spliced length of tensile plain bar embedded in unconfined high strength-high volume fly ash-self compacting concrete (HS-HVFA-SCC) beam.
Stefanus A. Kristiawan +2 more
doaj +1 more source
Splice-switching antisense oligonucleotides as therapeutic drugs
Nucleic Acids Research, 2016 Splice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the transcript by blocking the RNA–RNA base-pairing or protein–RNA binding ...
Mallory A. Havens, M. Hastings
semanticscholar +1 more source
European Journal of Combinatorics, 2011 We introduce and study a natural variant of matroid amalgams. For matroids M(A) and N(B) such that M/(A-B)=N(B-A), we define a splice of M and N to be a matroid L on the union of A and B with L(B-A)=M and L/(A-B)=N. We show that splices exist for each such pair of matroids M and N; furthermore, there is a freest splice of M and N, which we call the ...
Bonin, Joseph E., Schmitt, William R.
openaire +3 more sources
An experimental investigation on contact compression lap splice in circular columns
HBRC Journal, 2016 Due to the rapid development in design of multistory buildings and, because of the variation in stories height with the fixed length of the steel reinforcing bars, steel is usually wasted particularly in columns. Hence, compression lap splice may be used
Hamed S. Askar
doaj +1 more source
RNA Biology, 2023 Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and fewer alternative splice variants than mRNAs. Here, we have explored the efficiency of lncRNAs and mRNAs in producing various splice variants, given the number of exons
Koushiki Basu, Anubha Dey, Manjari Kiran
doaj +1 more source