Results 41 to 50 of about 394,248 (332)
RNA Biology, 2023 Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and fewer alternative splice variants than mRNAs. Here, we have explored the efficiency of lncRNAs and mRNAs in producing various splice variants, given the number of exons
Koushiki Basu, Anubha Dey, Manjari Kiran
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The pathobiology of splicing [PDF]
The Journal of Pathology, 2009 AbstractNinety‐four percent of human genes are discontinuous, such that segments expressed as mRNA are contained within exons and separated by intervening segments, called introns. Following transcription, genes are expressed as precursor mRNAs (pre‐mRNAs), which are spliced co‐transcriptionally, and the flanking exons are joined together to form a ...
Amanda J. Ward, Thomas A. Cooper
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Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. [PDF]
, 2016 Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies.
Abdallah, Walid F +9 more
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The Annals of Probability, 1983 Let X be a non-empty set, \({\mathcal A}\), \({\mathcal B}\) two \(\sigma\) -algebras on X, \({\mathcal C}_ 0\) the algebra generated by their union, \({\mathcal A}\bigvee {\mathcal B}\) the \(\sigma\) -algebra generated by \({\mathcal C}_ 0\); \(\mu\), \(\nu\) probability measures on \({\mathcal A}\), \({\mathcal B}\), respectively.
Kallianpur, G., Ramachandran, D.
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Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. [PDF]
Genes & Development, 1988 Based on ultrastructural analysis of actively transcribing genes seen in electron micrographs, we present evidence that pre-mRNA splicing occurs with a reasonable frequency on the nascent transcripts of early Drosophila embryo genes and that splice site selection may generally precede polyadenylation.
Yvonne N. Osheim, Ann L. Beyer
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BMC Bioinformatics, 2007 Background Algorithmic approaches to splice site prediction have relied mainly on the consensus patterns found at the boundaries between protein coding and non-coding regions.
Mount Stephen M +2 more
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Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing. [PDF]
PLoS ONE, 2015 Despite 20 years since its discovery, the gene responsible for Huntington's Disease, HTT, has still not had its function or transcriptional profile completely characterized. In response to a recent report by Ruzo et al.
Adam T Labadorf, Richard H Myers
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Modified SPLICE and its Extension to Non-Stereo Data for Noise Robust Speech Recognition
, 2013 In this paper, a modification to the training process of the popular SPLICE algorithm has been proposed for noise robust speech recognition. The modification is based on feature correlations, and enables this stereo-based algorithm to improve the ...
Joshi, Vikas +3 more
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OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L [PDF]
, 2007 OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice ...
Alexander, Christiane +4 more
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The strength of the HIV-1 3' splice sites affects Rev function
Retrovirology, 2006 Background The HIV-1 Rev protein is a key component in the early to late switch in HIV-1 splicing from early intronless (e.g. tat, rev) to late intron-containing Rev-dependent (e.g. gag, vif, env) transcripts.
Kjems Jørgen +5 more
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