Results 51 to 60 of about 394,248 (332)

Spliced leader RNA trans-splicing in dinoflagellates [PDF]

Proceedings of the National Academy of Sciences, 2007
Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Lilibeth Miranda, Yubo Hou, Terry Gaasterland, Nancy R. Sturm, Senjie Lin, David A. Campbell, Huan Zhang   +6 more
openaire   +3 more sources

Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels [PDF]

, 1991
The cloning of the cDNA for the α1 subunit of L-type calcium channels revealed that at least two genes (CaCh1 and CaCh2) exist which give rise to several splice variants.
Caffrey J. M., Catterall W. A., Ellis S. B., Glossmann H., Grabner M., Hofmann F., Hoshi T., Jay S. D., Jongh K. S., Kim H. S., Koch W. J., Koch W. J., Melton D. A., Olson E. N., Perez-Reyes E., Rampe D. E., Reuter H., Ruth P., Ruth P., Sambrook J., Sanger F., Schubert D., Shih H.-T., Snutch T. P., Tanabe T., Thomas P. S., Tsien R. W.   +26 more
core   +2 more sources

Widespread use of non-productive alternative splice sites in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
Saccharomyces cerevisiae has been used as a model system to investigate the mechanisms of pre-mRNA splicing but only a few examples of alternative splice site usage have been described in this organism.
Tadashi Kawashima, Stephen Douglass, Jason Gabunilas, Matteo Pellegrini, Guillaume F Chanfreau   +4 more
doaj   +1 more source

An operad for splicing [PDF]

Journal of Topology, 2012
34 pages, 16 diagrams. V3->V4: Explicit definition of sigma^* \wr G-operads given, and proof included splicing operad is such. Re-wrote proof of Theorem 5.13 to make the equivariance of the maps more explicit. Cut down on extraneous notation.
openaire   +3 more sources

Latent rank change detection for analysis of splice-junction microarrays with nonlinear effects

, 2011
Alternative splicing of gene transcripts greatly expands the functional capacity of the genome, and certain splice isoforms may indicate specific disease states such as cancer.
Burns, Suzanne, Burton, Tarea, Gelfond, Jonathan, Penalva, Luiz O. F., Sogayar, Mari, Zarzabal, Lee Ann   +5 more
core   +1 more source

Exploration of alternative splicing events in ten different grapevine cultivars [PDF]

, 2015
Background: The complex dynamics of gene regulation in plants are still far from being fully understood. Among many factors involved, alternative splicing (AS) in particular is one of the least well documented.
Asquini, Elisa, Cestaro, Alessandro, Coller, Emanuela, Potenza, Emilio, Racchi, Milvia Luisa, Sterck, Lieven, Tosatto, Silvio CE, Van de Peer, Yves, Velasco, Riccardo   +8 more
core   +7 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies [PDF]

, 2004
Versican is the principal large proteoglycan expressed in mid-tendon, but its role in tendon pathology is unknown. Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons,
Corps, AN, Costa, ML, Hazleman, BL, Ireland, DC, Movin, T, Riley, GP, Robinson, AHN   +6 more
core   +2 more sources

Rare occurrence of cryptic 5’ splice sites by downstream 3’ splice site/exon boundary mutations in a heavy-ion-induced egy1-4 allele of Arabidopsis thaliana

Frontiers in Plant Science
Pre-mRNA splicing is a fundamental process in eukaryotic gene expression, and the mechanism of intron definition, involving the recognition of the canonical GU (5’-splice site) and AG (3’-splice site) dinucleotides by splicing factors, has been ...
Alvin Sanjaya, Alvin Sanjaya, Ryo Nishijima, Yuki Fujii, Makoto Asano, Kotaro Ishii, Yusuke Kazama, Yusuke Kazama, Tomoko Abe, Makoto T. Fujiwara, Makoto T. Fujiwara   +10 more
doaj   +1 more source

EnsembleSplice: ensemble deep learning model for splice site prediction

BMC Bioinformatics, 2022
Background Identifying splice site regions is an important step in the genomic DNA sequencing pipelines of biomedical and pharmaceutical research. Within this research purview, efficient and accurate splice site detection is highly desirable, and a ...
Victor Akpokiro, Trevor Martin, Oluwatosin Oluwadare   +2 more
doaj   +1 more source