Results 61 to 70 of about 394,248 (332)
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Constructing Universal Abelian Covers of Graph Manifolds [PDF]
, 2010 To a rational homology sphere graph manifold one can associate a weighted tree invariant called splice diagram. It was shown earlier that the splice diagram determines the universal abelian cover of the manifold. We will in this article turn the proof of
Pedersen, Helge Møller
core
Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning [PDF]
, 2007 For modern biology, precise genome annotations are of prime importance, as they allow the accurate definition of genic regions. We employ state-of-the-art machine learning methods to assay and improve the accuracy of the genome annotation of the nematode
Bernhard Schölkopf +8 more
core +5 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
PLoS Genetics, 2022 Pre-mRNA splicing is an essential step of eukaryotic gene expression carried out by a series of dynamic macromolecular protein/RNA complexes, known collectively and individually as the spliceosome.
Jessie M N G L Suzuki +5 more
doaj +1 more source
An assessment of the strength of knots and splices used as eye terminations in a sailing environment [PDF]
, 2006 Research into knots, splices and other methods of forming an eye termination has been limited, despite the fact that they are essential and strongly affect the performance of a rope.
A. J. McLaren +20 more
core +1 more source
RNA splicing: a split consensus reveals two major 5′ splice site classes
Open BiologyThe established consensus sequence for human 5′ splice sites masks the presence of two major splice site classes defined by preferential base-pairing potentials with either U5 snRNA loop 1 or the U6 snRNA ACAGA box.
Matthew T. Parker +2 more
doaj +1 more source
Activation of cryptic splice sites in three patients with chronic granulomatous disease
Molecular Genetics & Genomic Medicine, 2019 Background Chronic granulomatous disease (CGD) is a primary immune deficiency caused by mutations in the genes encoding the structural components of the phagocyte NADPH oxidase.
Martin de Boer +3 more
doaj +1 more source
Discerning novel splice junctions derived from RNA-seq alignment: a deep learning approach
BMC Genomics, 2018 Background Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both possible ...
Yi Zhang +3 more
doaj +1 more source