Results 271 to 280 of about 483,589 (358)

Pathways of transcript splicing in yeast mitochondria. Mutations in intervening sequences of the split gene COB reveal a requirement for intervening sequence-encoded products.

, 1981
Carlo Schmelzer, Albert Haid, G. Grosch, Rudolf J. Schweyen, F. Kaudewitz   +4 more
openalex   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Identification of a <i>PATL2</i> missense variant (c.877G>T) disrupting canonical splicing and contributing to female infertility. [PDF]

Front Genet
Li H, Lin Y, Ma W, Yu T, Dong L, Chen Y, Fan S, Luo G, Zhang J, Song G.   +9 more
europepmc   +1 more source

Alternative splicing in aging and longevity

Human Genetics, 2019
Malini Bhadra, Porsha R. Howell, S. Dutta, Caroline Heintz, William B. Mair   +4 more
semanticscholar   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential. [PDF]

J Cell Mol Med
Ji C, Zhu J, Hou X, Zhou C, Zhao J, Zheng X, Tang Y.   +6 more
europepmc   +1 more source

Immunologically distinct p53 molecules generated by alternative splicing.

, 1986
Nobuyuki Arai, D Nomura, Kenji Yokota, D. Wolf, Eva Brill, O Shohat, Varda Rotter   +6 more
openalex   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets. [PDF]

Acta Neuropathol Commun
Fuentes-Fayos AC, G-García ME, Sánchez-Medianero T, Apps J, Flores-Martínez Á, De la Rosa-Herencia AS, Gil-Duque I, Otto G, Venegas-Moreno E, Ruiz-Valdepeñas EC, Herrera-Martínez AD, Solivera J, Gahete MD, Cano DA, Ortega R, Soto-Moreno A, Gálvez-Moreno MA, Martínez-Barberá JP, Luque RM.   +18 more
europepmc   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source