Results 281 to 290 of about 603,390 (338)

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

, 1984
Alberto R. Kornblihtt, Karen Vibe‐Pedersen, Francisco E. Baralle   +2 more
openalex   +2 more sources

CircLRBA Promotes Epithelial‐Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1

Advanced Science, EarlyView.
CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang, Xin Yang, Lei Xing, Hang Chen, Fuming Xie, Bin Wang, Bowen Shi, Yan Yang, Junxia Chen   +8 more
wiley   +1 more source

Dual Role of Transformer 2 Beta as Both a Developmental Necessity and a Disease Modulator. [PDF]

Int J Mol Sci
Swarup E, Qiu H.
europepmc   +1 more source

GDF15 Ameliorates Deoxynivalenol‐Induced Anemia by Resolving Ribosomal Stress–Mediated Erythropoietic Arrest

Advanced Science, EarlyView.
Deoxynivalenol induces anemia by disrupting hematopoietic homeostasis and impairing erythroid lineage commitment and differentiation via ribosomal stress–mediated G1/S cell cycle arrest. GDF15 supplementation alleviates this arrest through the β‐catenin–Myc–p21 signaling axis, highlighting GDF15 as a potential therapeutic target for DON‐induced ...
Yan Li, Peijun Jia, Jingxin Zhang, Huan Zhang, Bing Li, Jiawei Chang, Yating Li, Longzhen Zhao, Yazhe Zhen, Tingting Zheng, Yuanlin Xu, Xiuli An, Shijie Zhang   +12 more
wiley   +1 more source

Pan-tissue transcriptome analysis reveals sex-dimorphic human aging. [PDF]

Elife
Wang S, Dong D, Li X, Wang Z.
europepmc   +1 more source

Interpretation of RNA Universe and Coding Potential Using IntRNA

Advanced Science, EarlyView.
This study constructs a multi‐channel deep learning framework IntRNA to interpret RNA universe and coding potential. IntRNA consistently performed the best among existing methods in various benchmarks. Moreover, IntRNA’s interpretability is also validated by real‐world analysis, which found some features indicating long‐distance contact between ...
Yunxia Wang, Minjie Mou, Shijie Huang, Wei Zhang, Ziqi Pan, Jing Tang, Yihao Wang, Qingxia Yang, Feng Zhu   +8 more
wiley   +1 more source

<i>CSN1S1</i> and <i>CSN1S2</i>: Two Remarkable Examples of Genetically Modulated Alternative Splicing via Identification of Allele-Specific Splicing Events. [PDF]

Genes (Basel)
Cosenza G, Fulgione A, D'Anza E, Albarella S, Ciotola F, Pauciullo A.   +5 more
europepmc   +1 more source

beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.

, 1984
Stylianos E. Antonarakis, S H Irkin, Tiffany Cheng, Alan F. Scott, Julianne P. Sexton, Stephen P. Trusko, Samuel Charache, H H Kazazian   +7 more
openalex   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Genome-Wide Isoform Switching Reveals SR45-Mediated Splicing Control of <i>Arabidopsis</i> Leaf Senescence. [PDF]

Int J Mol Sci
Albaqami M, Almaghrabi GO.
europepmc   +1 more source