Results 291 to 300 of about 619,548 (333)

Controlled dynamic remodeling of the spliceosome active site enables the first step of splicing. [PDF]

Proc Natl Acad Sci U S A
Martino G, Manigrasso J, La Sala G, Marcia M, De Vivo M.   +4 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Detection of alternative splicing: deep sequencing or deep learning? [PDF]

Brief Bioinform
Hackl LM, Neuhaus F, Ameling S, Völker U, Baumbach J, Tsoy O.   +5 more
europepmc   +1 more source

RNA-Seq of Cultured Peripheral Blood Lymphocytes Improves Identification of Cryptic Splicing Defects in Rare Disease Diagnostics. [PDF]

Hum Mutat
Ren J, Dai C, Meng F, Zhang P, Xie C, Xiao W, He W, Yuan S, Li X, Zhang Q, Tang W, Hu L, Chen Z, Lu G, Du J, Zeng S, Lin G.   +16 more
europepmc   +1 more source

Synergistic intragenic epigenetic deregulation by IDH2 and SRSF2 mutations causes mis-splicing of key transcriptional regulators. [PDF]

Sci Adv
Telonis AG, Stanley RF, Adelman ER, Yoshimi A, Adele AA, Cruz A, Wiseman DH, Abdel-Wahab O, Figueroa ME.   +8 more
europepmc   +1 more source

P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions

Ying‐Ju Lin, Tsung‐Jung Ho, Ting-Hsu Lin, Wei-Yi Hsu, Shao-Mei Huang, Chiu-Chu Liao, Chih‐Ho Lai, Xiang Liu, Hsinyi Tsang, Chien‐Chen Lai, Fuu‐Jen Tsai   +10 more
openalex   +2 more sources

Using RNA-targeting CRISPR-Cas13 and engineered U1 systems to target <i>ABCA4</i> splice variants in Stargardt disease. [PDF]

Mol Ther Nucleic Acids
Liou RH, Urrutia-Cabrera D, Liu CF, Wu S, Westin IM, Golovleva I, Liu GS, Kumar S, McLenachan S, Chen FK, Hsu FT, Huang CL, Edwards T, Martin KR, Cheng AW, Wong RCB.   +15 more
europepmc   +1 more source