Results 301 to 310 of about 603,390 (338)

Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicing. [PDF]

PLoS Genet
Tomassoni-Ardori F, Palko ME, Galloux M, Tessarollo L.   +3 more
europepmc   +1 more source

CDK4/6 Inhibitor Priming Enhances PD‐1 Blockade via Sellhi Neutrophil‐Induced Stat5a+ Progenitor Exhausted CD8+ T Cell

Advanced Science, EarlyView.
Activated tumor‐intrinsic cyclin D1‐CDK4/6 signaling attenuates lymphocyte infiltration, and consequently, and immunotherapy resistance in HNSCC. It is discovered that brief CDK4/6i priming before anti‐PD‐1 results in enhanced durability of ICB response durability through Stat5a+ progenitor exhausted CD8+ T cells induced by IL15‐secreted Sell(hi ...
Yu Zhang, Bao Sun, Rong Zhou, Zizhen Gong, Yong Han, Wenjie Tao, Chaoji Shi, Wuchang Zhang, Laikui Liu, Zhiyuan Zhang, Jiang Li, Qi Zhu, Weiwen Zhu, Ziyue Gu   +13 more
wiley   +1 more source

Enzalutamide‐Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone‐Sensitive Prostate Cancer

Advanced Science, EarlyView.
Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wenhao Wang, Jing Zhao, Tiewen Li, Guangjian Fan, Jianong Zhang, Chenghao Zheng, Zhiwen Xie, Yu Zhang, Chengling Feng, Tianyu Cao, Jianyin Li, Guomin Ju, Di Cui, Shujie Xia, Bangmin Han   +14 more
wiley   +1 more source

Repair of Mutated <i>NF1</i> mRNA with Trans-Splicing Group I Intron Ribozymes. [PDF]

Cancers (Basel)
Leier A, Han X, Aghzadi J, Westin E, Liu J, Marquez Lago TT, Kesterson RA, Korf BR, Wallis D, Müller UF.   +9 more
europepmc   +1 more source

Multi‐Instably Mechanical Systems for Computing‐Storing Functions

Advanced Science, EarlyView.
Multi‐instably mechanical systems for the functions of scientific computing, logical operations, and data storage, i.e., solving fourth‐order ordinary differential equations (ODEs) by fourth‐order ODE solvers, realizing logical operations by digital logic gates, and stably storing data by mechanical memories.
Jiajun Wang, Chenjie Zhang, Qianyun Zhang, Pengcheng Jiao   +3 more
wiley   +1 more source

Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay. [PDF]

RNA Biol
Embree CM, Paul D, Stephanou A, Singh G.
europepmc   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Molecular characterization of a novel synonymous variant in a Mexican patient with Pompe disease. [PDF]

Mol Genet Metab Rep
Alaez-Verson C, González-Domínguez CA, Sanchez IV, Sanchez LMS, Flores IN, Kazakova E, Garcia-Solorio J, Molina-Garay C, Flores-Lagunes LL, Duncker IM.   +9 more
europepmc   +1 more source

Wafer‐Scale Manufacturing and Crack‐Free Transferring of GaN‐Based Membranes for Flexible Optoelectronics

Advanced Science, EarlyView.
QvdWE growth of III‐V nitrides on Gr/SiO2 not only helps to guide unified crystal orientation of GaN and improve crystalline quality, but also allows wafer‐level damage‐free GaN membrane to be easily transferred to foreign substrates through chemical etching of SiO2.
Yaqi Gao, Kaixuan Zhou, Zhetong Liu, Lulu Wang, Yiwei Duo, Shenyuan Yang, Jiankun Yang, Xiang Gao, Wenze Wei, Junxi Wang, Peng Gao, Jinmin Li, Zhongfan Liu, Jingyu Sun, Tongbo Wei   +14 more
wiley   +1 more source

Editorial: Post-transcriptional modifications in cancer immunity and immunotherapy. [PDF]

Front Immunol
Wei G, Zhou Y, Yue T, Zhang D.
europepmc   +1 more source