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Cell, 2023
Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction ...
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Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction ...
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Biosystems, 2018
This issue dedicated to the code of life tackles very challenging and open questions in Biology. The genetic code, brilliantly uncovered over 50 years ago is an example of a univocal biological code. In fact, except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5' GUGUUC 3' reads as the dipeptide: Val-Phe ...
Marco Baralle, Francisco E. Baralle
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This issue dedicated to the code of life tackles very challenging and open questions in Biology. The genetic code, brilliantly uncovered over 50 years ago is an example of a univocal biological code. In fact, except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5' GUGUUC 3' reads as the dipeptide: Val-Phe ...
Marco Baralle, Francisco E. Baralle
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ACM SIGCOMM Computer Communication Review, 2008
We present path splicing, a new routing primitive that allows network paths to be constructed by combining multiple routing trees ("slices") to each destination over a single network topology. Path splicing allows traffic to switch trees at any hop en route to the destination.
Nick Feamster +3 more
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We present path splicing, a new routing primitive that allows network paths to be constructed by combining multiple routing trees ("slices") to each destination over a single network topology. Path splicing allows traffic to switch trees at any hop en route to the destination.
Nick Feamster +3 more
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BioEssays, 1994
AbstractConsiderable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression,
Robin Holliday, Vincent Murray
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AbstractConsiderable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression,
Robin Holliday, Vincent Murray
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Nature Chemical Biology, 2018
Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
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Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
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The splice of life: Alternative splicing and neurological disease
Nature Reviews Neuroscience, 2001Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases.
Dredge, B., Polydorides, A., Darnell, R.
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Spliced leader RNA trans-splicing in metazoa
Parasitology Today, 1996Spliced leader trans-splicing is a form of RNA processing originally described and studied in parasitic kinetoplastida. This mechanism of gene expression also occurs in parasitic and free-living metazoa. In this review, Dick Davis describes current knowledge of the distribution, substrates, specificity and functional significance of trans-splicing in ...
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