Results 311 to 320 of about 603,390 (338)

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid‐Liquid Phase Separation

Advanced Science, EarlyView.
Muscle‐specific RPS27L knock‐in mice exhibit increased body weight, muscle mass, and enhanced muscle regenerative capacity. RPS27L drives myogenesis by promoting myoblast proliferation, while inhibiting myogenic differentiation. Mechanistically, RPS27L targets IGF1 protein by liquid‐liquid phase separation through its N‐terminal intrinsically ...
Xiaoqin Liu, Yilong Yao, Junyu Yan, Mu Zeng, Xinhao Fan, Yijie Tang, Jiju Li, Yanwen Liu, Shanying Yan, Wei Wang, Lijuan Chen, Ruipu Chen, Yuxin Huang, Honor Calnan, Heng Wang, Graham Gardner, Yalan Yang, Zhonglin Tang   +17 more
wiley   +1 more source

ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis. [PDF]

Nat Commun
Chang X, Li W, Matsui S, Huynh C, Erickson C, Guo F, Cederquist GY, Studer L, Iwafuchi M, Shillington A, Chronis C, Tchieu J.   +11 more
europepmc   +1 more source

Regulation of transcriptome plasticity by mTOR signaling pathway. [PDF]

Exp Mol Med
Yong J, Kim H, Lee E, Jung Y.
europepmc   +1 more source

Cataloging the potential functional diversity of Cacna1e splice variants using long-read sequencing. [PDF]

BMC Genomics
Bhuiyan SA, Tyson JR, Belmadani M, Sicherman J, Snutch TP, Pavlidis P.   +5 more
europepmc   +1 more source

RNA <i>trans</i>-splicing to rescue β-catenin: A novel approach for treating CTNNB1-Haploinsufficiency disorder. [PDF]

Mol Ther Nucleic Acids
Maruna M, Sušjan-Leite P, Meško M, Miroševič Š, Jerala R.   +4 more
europepmc   +1 more source

Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds. [PDF]

PLoS Pathog
Cheng W, Gu M, Wang Y, Wang J, Li S, Chen G, Chen X, Oyeyemi OT, Hong Y, Hu W, Wang J.   +10 more
europepmc   +1 more source

Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan

Hayman DJ, Simons MJP.
europepmc   +1 more source

A novel truncating variant c.1222DupC in RBM20 causes cardiomyopathy through haploinsufficiency

Pant P, Huang Y, Ghouse Z, Bai F, Kemmling E, Konrad L, Kistler R, Seeger T, Gotthardt M, Parikh VN, van den Hoogenhof MM.   +10 more
europepmc   +1 more source

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Sweet splicing

Cell, 2023
Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction ...
openaire   +3 more sources