Results 321 to 330 of about 483,589 (358)
Some of the next articles are maybe not open access.
RNA Splicing by the Spliceosome.
Annual Review of Biochemistry, 2019The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing.
M. E. Wilkinson, C. Charenton, K. Nagai
semanticscholar +1 more source
Cell, 2023
Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction ...
openaire +3 more sources
Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction ...
openaire +3 more sources
Biosystems, 2018
This issue dedicated to the code of life tackles very challenging and open questions in Biology. The genetic code, brilliantly uncovered over 50 years ago is an example of a univocal biological code. In fact, except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5' GUGUUC 3' reads as the dipeptide: Val-Phe ...
Marco Baralle, Francisco E. Baralle
openaire +3 more sources
This issue dedicated to the code of life tackles very challenging and open questions in Biology. The genetic code, brilliantly uncovered over 50 years ago is an example of a univocal biological code. In fact, except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5' GUGUUC 3' reads as the dipeptide: Val-Phe ...
Marco Baralle, Francisco E. Baralle
openaire +3 more sources
ACM SIGCOMM Computer Communication Review, 2008
We present path splicing, a new routing primitive that allows network paths to be constructed by combining multiple routing trees ("slices") to each destination over a single network topology. Path splicing allows traffic to switch trees at any hop en route to the destination.
Nick Feamster +3 more
openaire +2 more sources
We present path splicing, a new routing primitive that allows network paths to be constructed by combining multiple routing trees ("slices") to each destination over a single network topology. Path splicing allows traffic to switch trees at any hop en route to the destination.
Nick Feamster +3 more
openaire +2 more sources
BioEssays, 1994
AbstractConsiderable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression,
Robin Holliday, Vincent Murray
openaire +3 more sources
AbstractConsiderable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression,
Robin Holliday, Vincent Murray
openaire +3 more sources
Nature Chemical Biology, 2018
Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
openaire +3 more sources
Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
openaire +3 more sources
Alternative splicing as a source of phenotypic diversity
Nature reviews genetics, 2022Charlotte J. Wright +2 more
semanticscholar +1 more source
The physiology of alternative splicing
Nature reviews. Molecular cell biology, 2022Luciano E Marasco, A. Kornblihtt
semanticscholar +1 more source
The splice of life: Alternative splicing and neurological disease
Nature Reviews Neuroscience, 2001Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases.
Dredge, B., Polydorides, A., Darnell, R.
openaire +4 more sources
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Nature reviews genetics, 2022M. Rogalska +2 more
semanticscholar +1 more source