Results 321 to 330 of about 603,390 (338)
Some of the next articles are maybe not open access.
Biosystems, 2018
This issue dedicated to the code of life tackles very challenging and open questions in Biology. The genetic code, brilliantly uncovered over 50 years ago is an example of a univocal biological code. In fact, except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5' GUGUUC 3' reads as the dipeptide: Val-Phe ...
Marco Baralle, Francisco E. Baralle
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This issue dedicated to the code of life tackles very challenging and open questions in Biology. The genetic code, brilliantly uncovered over 50 years ago is an example of a univocal biological code. In fact, except for very few and marginal variations, it is the same from bacteria to man, the RNA stretch: 5' GUGUUC 3' reads as the dipeptide: Val-Phe ...
Marco Baralle, Francisco E. Baralle
openaire +3 more sources
ACM SIGCOMM Computer Communication Review, 2008
We present path splicing, a new routing primitive that allows network paths to be constructed by combining multiple routing trees ("slices") to each destination over a single network topology. Path splicing allows traffic to switch trees at any hop en route to the destination.
Nick Feamster +3 more
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We present path splicing, a new routing primitive that allows network paths to be constructed by combining multiple routing trees ("slices") to each destination over a single network topology. Path splicing allows traffic to switch trees at any hop en route to the destination.
Nick Feamster +3 more
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BioEssays, 1994
AbstractConsiderable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression,
Robin Holliday, Vincent Murray
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AbstractConsiderable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression,
Robin Holliday, Vincent Murray
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Nature Chemical Biology, 2018
Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
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Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
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The splice of life: Alternative splicing and neurological disease
Nature Reviews Neuroscience, 2001Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases.
Dredge, B., Polydorides, A., Darnell, R.
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Spliced leader RNA trans-splicing in metazoa
Parasitology Today, 1996Spliced leader trans-splicing is a form of RNA processing originally described and studied in parasitic kinetoplastida. This mechanism of gene expression also occurs in parasitic and free-living metazoa. In this review, Dick Davis describes current knowledge of the distribution, substrates, specificity and functional significance of trans-splicing in ...
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Nature Reviews Genetics, 2012 Splicing and Alternative Splicing and the Impact of Mechanics
2020Systems-wide approaches have gained new insights into mRNA splicing. Improved cryo-EM techniques have elucidated the structure of splice components. Recent findings on the molecular architecture of the human spliceosome are unveiled. In complement to the normal splicing of introns out of DNA sequences, alternative splicing is also examined.
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Editorial – splicing and alternative splicing
The International Journal of Biochemistry & Cell Biology, 2019Hugo Miguel Baptista Carreira dos Santos +3 more
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2017
Connectors and splices link the ends of two fibers both optically and mechanically. The two are not interchangeable. A connector is mounted on the end of a cable or optical device so it can be attached to other cables or devices. Like electrical connectors, fiberoptic connectors can be plugged and unplugged. In contrast, splices are permanent junctions
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Connectors and splices link the ends of two fibers both optically and mechanically. The two are not interchangeable. A connector is mounted on the end of a cable or optical device so it can be attached to other cables or devices. Like electrical connectors, fiberoptic connectors can be plugged and unplugged. In contrast, splices are permanent junctions
openaire +2 more sources