Results 161 to 170 of about 376,518 (330)
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Advanced Science, EarlyView.This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen +31 more
wiley +1 more source
Advanced Science, EarlyView.Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang +9 more
wiley +1 more source
Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants
Advanced Science, EarlyView.In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao +12 more
wiley +1 more source
Splicing factor SRSF1 limits IFN-γ production via RhoH and ameliorates experimental nephritis
, 2020 Takayuki Katsuyama +4 more
openalex +2 more sources
The splicing factor SRSF6 regulates AR activity and represents a potential therapeutic target in prostate cancer [PDF]
, 2023 Juan M. Jiménez‐Vacas +19 more
openalex +1 more source
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
Advanced Science, EarlyView.PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing
Advanced ScienceThe progression of spermatogenesis along specific developmental trajectories depends on the coordinated regulation of pre‐mRNA alternative splicing (AS) at the post‐transcriptional level.
Shiyu Wang +15 more
doaj +1 more source