Results 161 to 170 of about 226,212 (308)

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

iCLIP predicts the dual splicing effects of TIA-RNA interactions

, 2010
The regulation of alternative splicing involves interactions between RNA-binding proteins and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and TIA1-like 1 (TIAL1) locally enhance exon inclusion by recruiting U1 ...
Nicholas M. Luscombe, Wang, Zheng, Zarnack, Kathi, Jernej Ule, Kayikci Melis, Rot, Gregor, Curk, Tomaz, Ule, Jernej, Zhen Wang, Luscombe, Nicholas M, Kathi Zarnack, Briese Michael, Zupan Blaž, Michael Briese, Melis Kayikci, Blaž Zupan, Ule Jernej, Wang Zhen, Zupan, Blaz, Zarnack Kathi, Luscombe Nicholas M., Briese, Michael, Curk Tomaž, Nicholas M Luscombe, Gregor Rot, Rot Gregor, Tomaž Curk, Kayikci, Melis   +27 more
core   +1 more source

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

FiN‐Kiri: Fabric‐Based Inflatable Kirigami Actuator for Multimodal Soft Robots

Advanced Robotics Research, EarlyView.
This study introduces a type of inflatable fabric‐based kirigami actuator capable of performing bending motion. The actuator is utilized as soft grippers, a crawling robot and a swimming robot. The crawling robot demonstrated extraordinary motion capabilities, such as moving forward, turning and navigating a narrow tunnel.
Yang Yu, Yupei Zhang, Yanqi Yin, Yehui Wu, Jinyao Zhang, Ruiyu Bai, Jiaqiang Yao, Kewei Su, Chenyi Yu, Zhicheng Tian, Naipeng Li, Zhuang Zhang, Bo Li   +12 more
wiley   +1 more source

Understanding the mechanisms of Proteasome-Mediated Peptide Splicing by Comparing Splicing Efficiency by Different Proteasome Subtypes

, 2023
Anti-tumor CD8+ T cells recognize peptides of 8-to-10 amino acids that are presented at the surface of tumors by molecules of the major histocompatibility complex I (MHC I). These peptides generally result from the degradation of cellular proteins by the
Vigneron, Nathalie, Van den Eynde, Benoit, 5th International Caparica Conference in SPLICING 2023, Stroobant, Vincent, Ferrari, Violette   +4 more
core  

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Development and disease-specific regulation of RNA splicing in cardiovascular system

Frontiers in Cell and Developmental Biology
Alternative splicing is a complex gene regulatory process that distinguishes itself from canonical splicing by rearranging the introns and exons of an immature pre-mRNA transcript. This process plays a vital role in enhancing transcriptomic and proteomic
Jinxiu Jiang, Hongchun Wu, Yabo Ji, Kunjun Han, Jun-Ming Tang, Shijun Hu, Wei Lei   +6 more
doaj   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source