Results 221 to 230 of about 376,518 (330)

Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma. [PDF]

open access: yesSci Adv
Guo Y   +10 more
europepmc   +1 more source

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

open access: yesAdvanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu   +23 more
wiley   +1 more source

Editorial: Alternative Splicing Regulation in Plants

open access: yesFrontiers in Plant Science, 2020
Ezequiel Petrillo   +6 more
doaj   +1 more source

Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30. [PDF]

open access: yesJ Biol Chem
Izumikawa K   +11 more
europepmc   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

open access: yesAdvanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme   +12 more
wiley   +1 more source

Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing [PDF]

open access: bronze, 2010
Ylva Mende   +8 more
openalex   +1 more source

Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation

open access: gold, 2022
Renpeng Ji   +8 more
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

open access: yesAdvanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang   +9 more
wiley   +1 more source

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