Results 71 to 80 of about 96,608 (254)
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Tabu search optimization of forest road alignments combined with shortest paths and cubic splines
Croatian Journal of Forest Engineering, 2006 This paper describes a program for optimizing forest road alignments using the Dijkstra shortest path method and a cubic spline function.We previously developed a method for optimizing forest road alignments once a series of intersection points (IPs ...
Kazuhiro Aruga +3 more
doaj +2 more sources
Particle filter with spline resampling and global transition model
IET Computer Vision, 2015 The authors introduce the concept of a spline resampling in the particle filter to deal with high accuracy and sample impoverishment. The resampling is usually based on a linear transformation on the weights of the particles, so it affects the filtering ...
Gwangmin Choe +4 more
doaj +1 more source
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Advanced Science, EarlyView.Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source
MachinesSpline couplings endure various external loads during operation, which induce complex variations in contact surfaces and significantly affect their stiffness behavior. This research focuses on a specific spline coupling to analyze its nonlinear stiffness
Chongbei Huang, Yinli Feng
doaj +1 more source
Construction of B-spline surface from cubic B-spline asymptotic quadrilateral
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017 Asymptote is widely used in astronomy, mechanics, architecture and relevant subjects. In this paper, by analyzing the Frenet frame and the Darboux frame of a curve on the surface, the necessary and sufficient conditions for a quadrilateral boundary being
Hui WANG, Chun-Gang ZHU, Cai-Yun LI
doaj +1 more source
Advanced Science, EarlyView.Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie +12 more
wiley +1 more source
Advanced Science, EarlyView.EndoTac presents a trocar‐compatible endoscopic vision‐based tactile sensor that uses a convex mirror to enlarge side‐facing tactile coverage during minimally invasive vessel palpation. Distorted tactile images are unwarped and processed by a learning model to estimate vascular deformation, enabling sensitive, spatially distributed tactile perception ...
Yupeng Wang +5 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue
Advanced Science, EarlyView.This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg +19 more
wiley +1 more source