Results 121 to 130 of about 621,908 (253)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Performance of grape marc and organic residues compost as substrate in lettuce (Lactuca sativa) seedlings

open access: yesRevista de la Facultad de Ciencias Agrarias, 2019
Composting is an aerobic process used to treat organic residues, which results in a high quality product, able to be adopted as plant substrate or soil amendment. In the present study, the performance of compost on the germination and biomass of Lactuca
Iván Funes Pinter   +5 more
doaj  

A split-plot experiment with factor-dependent whole-plot sizes

open access: yes, 2011
Problem: The dairy company FrieslandCampina had an opportunity to redesign the production process for its coffee cream. This product has a very specific viscosity, and the redesigned process had to result in the same viscosity as the old one.
Bradley Jones   +11 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Optimal split^{k}-plot$ designs

open access: yes
: Completely randomized designs are often infeasible due to the hard-to-change nature of one or more experimental factors. In those cases, restrictions are imposed on the order of the experimental tests. The resulting experimental designs are often split-
Born, Mathias, Goos, Peter
core  

Układ split-split-plot dla nieortogonalnego doświadczenia z łubinem

open access: yes, 2015
In the paper a construction method of an incomplete split-split-plot (SSP) design for a non-orthogonal experiment is presented. Incompleteness of the SSP design concerns sub-subplot treatments. Balanced incomplete block (BIB) design is used as generating
Ambroży-Deręgowska, Katarzyna   +1 more
core  

Incomplete Data in Split-Plot, Split-Block, and Other Similar Designs [PDF]

open access: yes, 1965
15 pages, 1 article*Incomplete Data in Split-Plot, Split-Block, and Other Similar Designs* (Federer, W.
Cornell University. Dept. of Biological Statistics and Computational Biology.   +3 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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