Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
A Simulated Study Of Smallholder Dairy Production Systems [PDF]
, 1989 Four experiments were conducted to investigate the productive performance of Sahiwal-Friesian cows under different feeding managements. Rotational grazing at stocking rate 6.25 milking cows ( AU ) / ha on Setaria splendida and stall- fed cut Panicum ...
Soetrisno, R. Djoko
core
Split-plot marine experiment to assess ecophysiological responses of Gelidium corneum assemblages
, 2023 N. Muguerza +6 more
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Algunas soluciones aproximadas para diseños split-plot con matrices de covarianza arbitrarias [PDF]
, 1998 El presente trabajo revisa con cierto detalle diversos tipos de análisis para diseños split-plot que carecen del mismo número de unidades experimentales dentro de cada grupo y en los que se incumple el supuesto de esfericidad multimuestral ...
Escudero García, J. R. +1 more
core +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
The effect of nitrogen, fungicide, time and method of harvest on seed quality in super sweetcorn (Zea mays L.) cv. Illini gold : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Plant Science (Seed Technology) at Massey University [PDF]
, 1996 Super sweetcorn (Zea mays L.) poses problems for seed production, because the high seed sugar levels delay seed drying, which means harvest delays and the encouragement of pathogen invasion. These factors reduce seed quality, particularly germination and
Chompukeaw, Winai
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source