Results 111 to 120 of about 1,509,952 (299)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Evaluation of Proposed Rocket Engines for Earth-to-Orbit Vehicles [PDF]

The objective is to evaluate recently analyzed rocket engines for advanced Earth-to-orbit vehicles. The engines evaluated are full-flow staged combustion engines and split expander engines, both at mixture ratios at 6 and above with oxygen and hydrogen ...
Kramer, Richard D., Martin, James A.
core   +1 more source

Split Supersymmetry in Unified Models

, 2005
In the context of split supersymmetry, the gaugino mass spectrum seems to be very important to satisfy the dark matter content of the universe and the gauge coupling unification.
Allahverdi, Anchordoqui, Antoniadis, Arkani-Hamed, Arkani-Hamed, Arvanitaki, Arvanitaki, Babu, Bajc, Beccaria, Bhaskar Dutta, Binger, Bjorkman, Bousso, Chen, Chen, Chen, Chen, Cheung, Cheung, Chun, Datta, Demir, Denef, Denef, Diaz, Dimopoulos, Dine, Dine, Dine, Douglas, Douglas, Douglas, Douglas, Drees, Edsjo, Eidelman, Einhorn, Feng, Gao, Giudice, Giudice, Giudice, Giudice, Gondolo, Gupta, Haba, Haba, Hewett, Hisano, Hisano, Huitu, Ibanez, Jones, Kachru, Kasuya, Kilian, Kokorelis, Kors, Machacek, Machacek, Mahbubani, Marandella, Marciano, Martin, Martin, Masiero, Mukhopadhyaya, Perlmutter, Pierce, Randall, Sarkar, Schuster, Senatore, Silverstein, Spergel, Susskind, Susskind, Vereshkov, Weinberg, Wells, Yamada, Yukihiro Mimura, Zhu   +83 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Delay Minimizing User Association in Cellular Networks via Hierarchically Well-Separated Trees

, 2015
We study downlink delay minimization within the context of cellular user association policies that map mobile users to base stations. We note the delay minimum user association problem fits within a broader class of network utility maximization and can ...
Osmanlioglu, Yusuf, Shokoufandeh, Ali, Weber, Steven, Wildman, Jeffrey   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

影响功率分流无级变速器效率的主要参数研究

Jixie chuandong, 2014
Two classic ways of working of the hydra-mechanical power split CVT are studied.The efficiency formula of power-split is derived by definition,the power split ratio is studied,and the influence of different parameters on system efficiency is analyzed.The
韩梅梅, 高翔
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source