Results 81 to 90 of about 392,166 (257)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Analysis of the Flow Capacity of Variable Cycle Split Fans at the Middle Speed
EnergiesThe next-generation variable cycle engine imposes stricter requirements on a fan’s flow capacity at the middle speed. To tackle this challenge, the implementation of split fans presents as a potential solution.
Guangfeng An +4 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2021 Cilj: Prikazati karakteristike kliničke slike, dijagnostike i liječenja pacijenata liječenih od kala-azara na Klinici za infektologiju KBC-a Split i MEFST-a u razdoblju od 1.siječnja 2000. do 31.prosinca 2019. godine.
Laco, Matea
core
Study on Transmission Characteristics of Hydrodynamic Split Torque Converter
工程科学与技术, 2009 :Based on equations of motion of 2K-H planetary gear trains, given a determine method of self locking of hydrodynamic power split torque converter (HSTC); Put forward an analysis method of power flow of HSTC; and established the relationships between ...
Li Hua, YAO Jin
doaj
Optimal Operation of Dividing Wall Column using Enhanced Active Vapor Distributor
Chemical Engineering Transactions, 2018 Due to its outstanding energy and capital cost-saving potential, a dividing wall column (DWC) has gained importance for the last two decades. Unlike conventional distillation columns, the DWC has more design and operation variables, such as controlling ...
Rionugroho Harvianto Gregorius +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Machine Learning-Driven Framework for Optimal Split Ratio Determination in PMSM Design
IEEE AccessThe split ratio, which is the ratio of rotor diameter to stator diameter, plays a pivotal role in determining the performance of permanent magnet (PM) motors. This study presents a machine learning-driven framework to optimize the split ratio from a cost-
Ju Hyung Lee +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source