Results 91 to 100 of about 31,903 (270)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A variation norm Carleson theorem [PDF]

, 2009
We strengthen the Carleson-Hunt theorem by proving $L^p$ estimates for the $r$-variation of the partial sum operators for Fourier series and integrals, for $p>\max\{r',2\}$.
Oberlin, Richard, Seeger, Andreas, Tao, Terence, Thiele, Christoph, Wright, James   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Inertial Halpern-type iterative algorithm for the generalized multiple-set split feasibility problem in Banach spaces

Journal of Inequalities and Applications
In this paper, we study the generalized multiple-set split feasibility problem including the common fixed-point problem for a finite family of generalized demimetric mappings and the monotone inclusion problem in 2-uniformly convex and uniformly smooth ...
Mohammad Eslamian
doaj   +1 more source

Strong Convergence of a New Generalized Viscosity Implicit Rule and Some Applications in Hilbert Space

Mathematics, 2019
In this paper, based on the very recent work by Nandal et al. (Nandal, A.; Chugh, R.; Postolache, M. Iteration process for fixed point problems and zeros of maximal monotone operators.
Mihai Postolache, Ashish Nandal, Renu Chugh   +2 more
doaj   +1 more source

Adaptive FE-BE coupling for strongly nonlinear transmission problems with friction II

, 2013
This article discusses the well-posedness and error analysis of the coupling of finite and boundary elements for transmission or contact problems in nonlinear elasticity.
Gimperlein, Heiko, Stephan, Ernst P.
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Convergence analysis of a variable metric forward–backward splitting algorithm with applications

Journal of Inequalities and Applications, 2019
The forward–backward splitting algorithm is a popular operator-splitting method for solving monotone inclusion of the sum of a maximal monotone operator and an inverse strongly monotone operator.
Fuying Cui, Yuchao Tang, Chuanxi Zhu
doaj   +1 more source