Results 71 to 80 of about 31,903 (270)
Alexandria Engineering JournalIn this article, we present two inertial modifications of regularized algorithms for the split variational inclusion problem (SVIP, for short) in real Hilbert spaces (RHSs).
Hasanen A. Hammad +2 more
doaj +1 more source
Generalized Forward-Backward Splitting
, 2012 This paper introduces the generalized forward-backward splitting algorithm for minimizing convex functions of the form $F + \sum_{i=1}^n G_i$, where $F$ has a Lipschitz-continuous gradient and the $G_i$'s are simple in the sense that their Moreau ...
Bricen͂o-Arias L. M. +12 more
core +5 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A general viscosity implicit iterative algorithm for split variational inclusions with hierarchical variational inequality constraints [PDF]
Fixed Point Theory, 2019 Summary: The purpose of this paper is to introduce a general viscosity implicit iterative method for finding a solution of a split variational inclusion problem (SVIP) with a hierarchical variational inequality (HVI) constraint for a countable family of nonexpansive mappings in Hilbert spaces.
Ceng, L. C. +3 more
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Mathematics, 2019 Based on the very recent work by Shehu and Agbebaku in Comput. Appl. Math. 2017, we introduce an extension of their iterative algorithm by combining it with inertial extrapolation for solving split inclusion problems and fixed point problems.
Pawicha Phairatchatniyom +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Geometry and symmetry of quantum and classical-quantum variational principles
, 2015 This paper presents the geometric setting of quantum variational principles and extends it to comprise the interaction between classical and quantum degrees of freedom.
Luz, Esther Bonet, Tronci, Cesare
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source