Results 111 to 120 of about 51,797 (271)

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Transthoracic Echocardiography findings in patients with Ankylosing Spondylitis in Kurdistan region

Advanced Medical Journal
Background and objectives: Ankylosing spondylitis is a chronic inflammatory disorder that affecting axial and non-axial joints leads to a loss of mobility and function over time.
Elaf Kamal Abdulwahab, Dashty Abbas Albustany   +1 more
doaj   +1 more source

Osteoporosis in Patients with Ankylosing Spondylitis - Review

, 2007
Osteoporosis (OP) is now well recognized in patients with ankylosing spondylitis (AS). Vertebral fractures that result from osteoporosis are a feature of longstanding AS. In AS, diagnosis of osteoporosis is still often a challenge.
Yasemin Dinçer Turan, Mehmet Tuncay Duruöz   +1 more
core  

Risk of urinary tract infection with SGLT2 inhibitor initiation in patients with immune‐mediated inflammatory diseases and type 2 diabetes: A target trial emulation using a Japanese hospital‐based claims database

Journal of Diabetes Investigation, EarlyView.
In this target trial emulation of patients with immune‐mediated inflammatory diseases and type 2 diabetes, SGLT2 inhibitor initiation was not associated with a clear increase in UTI risk versus metformin, including across immunosuppressive therapy strata.
Hiroshi Tsushima, Nobuyuki Yajima, Takashi Nomiyama, Ryoko Sakai, Hisashi Noma, Akira Katagiri, Naoto Tamura   +6 more
wiley   +1 more source

Asian Pacific Association of Gastroenterology (APAGE) Clinical Practice Guidelines on the Use of Small Molecules and IL‐23 p19 Inhibitors in Ulcerative Colitis and Crohn's Disease

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Ulcerative colitis (UC) and Crohn's disease (CD) are increasingly prevalent in the Asia Pacific region, necessitating updated, region‐specific guidance on advanced therapies. Targeted small molecule agents, such as filgotinib, tofacitinib, upadacitinib, etrasimod, and ozanimod; and the IL‐23 p19 inhibitors (guselkumab, mirikizumab ...
Choon Jin Ooi, Khoon Lin Ling, Julajak Limsrivilai, Shu‐Chen Wei, Joyce Wing Yan Mak, Taku Kobayashi, Luan Minh Dang, Rupert W. Leong, Huiyu Lin, Meng‐Tzu Weng, Wan Chee Ong, Vineet Ahuja, Satimai Aniwan, Ryota Hokari, Wei Jie Jonathan Lee, Alex Hwong‐Ruey Leow, Wai‐Keung Leung, Wee‐Chian Lim, Govind Makharia, Katsuyoshi Matsuoka, Nazri Mustaffa, Siew‐Chien Ng, Mathew Philip, Pises Pisespongsa, Raja Affendi Raja Ali, Zhi Hua Ran, Marcellus Simadibrata, Jose Sollano, Malcolm Tan, Hang Dao Viet, Nik Razima Wan Ibrahim, Kai Chun Wu, Byong Duk Ye, Ida Hilmi, Asian Pacific Association of Gastroenterology (APAGE) Inflammatory Bowel Disease Committee and Asian Education Network in IBD (AEN‐IBD)   +34 more
wiley   +1 more source

Geographic Variation in Diagnostic Ability and Quality of Care Metrics: A Case Study of Ankylosing Spondylitis and Low Back Pain

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2017
Studies examining geographic variation in care for low back pain often focus on process and outcome measures conditional on patient diagnosis but generally do not take into account a physician’s ability to diagnose the root cause of low back pain. In our
Jason Shafrin PhD, Jenny Griffith PharmD, Jin Joo Shim MS, Caroline Huber MPH, Arijit Ganguli PhD, MBA, Wade Aubry MD   +5 more
doaj   +1 more source

Bone Mineral Density Assessment in Ankylosing Spondylitis and Characteristics of Bone Turnover Parameters

, 2005
Ankylosing spondylitis, characterised with excessive new bone formation and calcification in spine and peripheral joints, causes osteoporosis which is a general component of inflammatory arthritis.
Banu Kuran, Füsun Şahin, Nurdan Kotevoğlu   +2 more
core  

Coexistence of rheumatoid arthritis and ankylosing spondylitis

, 2015
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic progressive inflammatory diseases, leading to joint damage and reducing the physical fitness of patients. They are among the most common rheumatic diseases. However, their etiology and
Marta Dura, Paweł Żuchowski, Sławomir Jeka, Tacjana Anna Barczyńska, Małgorzata Węgierska, Marzena Waszczak, Joanna Zalewska   +6 more
core   +1 more source

Incidence and Management of Cerebrospinal Fluid Leakage due to Late Presentation of Dural Tears After Lumbar Surgery

Orthopaedic Surgery, EarlyView.
This article reveals a 0.3% incidence of LPDT and highlights the importance of increased clinical awareness. Furthermore, appropriate management to optimize patient recovery and minimize long‐term complications. ABSTRACT Objective To investigate the incidence and treatment of cerebrospinal fluid leakage due to late presentation of dural tears (LPDT ...
Xiaoxiong Yang, Dazhao Tie, Rui Chen, Xin Chen, Yanbin Zhao, Hua Zhou, Yan Li, Lei Dang, Chuiguo Sun, Feifei Zhou   +9 more
wiley   +1 more source

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?

Clinics
OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene.
Ismail Sari, Yusuf Ziya Igci, Gercek Can, Ali Taylan, Dilek Solmaz, Bulent Gogebakan, Servet Akar, Zeynep Eslik, Giray Bozkaya, Nurullah Akkoc   +9 more
doaj   +1 more source