Pleiotropic effects of netakimab in patients with psoriatic arthritis, spondylitis and comorbid metabolic syndrome or a new opportunity for weight control? Case report [PDF]
Терапевтический архивThe article presents the results of studying the efficacy of netakimab (Efleira) in the complex treatment of patients with psoriasis, psoriatic arthritis, spondylitis and concomitant metabolic syndrome.
Alida K. Karibova +3 more
doaj +1 more source
Frontiers in Microbiology, 2023 IntroductionEpidemiological and clinical analyses of brucellosis are vital for public health leaders to reinforce disease surveillance and case management strategies.MethodsIn this study, we aimed to analyse the epidemiology and clinical features of 1 ...
Bofei Liu +8 more
doaj +1 more source
A Review of Ankylosing Spondylitis [PDF]
, 2017 Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core +1 more source
Advanced Science, EarlyView.This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi +11 more
wiley +1 more source
Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]
, 1993 In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A. +2 more
core
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Nonsteroidal anti-inflammatory drugs: a basis for the treatment of ankylosing spondylitis
Современная ревматология, 2011 The paper describes the pathomorphological aspects of ankylosing spondylitis (AS) and the value of nonsteroidal anti-inflammatory drugs in its therapy. Clinical trials demonstrate the high efficacy of aceclofenac (aertal) in AS.
A A Godzenko
doaj +1 more source
Persistencia de medicamentos biológicos durante ocho años en pacientes con artritis reumatoide y espondiloartritis [PDF]
, 2019 Objective: To calculate the persistence, over a period of eight years, the retention rate of first and second-line of treatment with biological agents in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis and to compare ...
Balsa, Alejandro +5 more
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Assessing the association of leukocyte telomere length with ankylosing spondylitis and rheumatoid arthritis: A bidirectional Mendelian randomization study [PDF]
, 2023 Donglei Wei +5 more
openalex +1 more source
Mucosal‐Associated Invariant T Cells in Rheumatic Diseases
Arthritis &Rheumatology, EarlyView.Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek +7 more
wiley +1 more source